Abstract
Are there enough mast cells in denervated skeletal muscle to account for autopharmacological mediation of the antigen potentials (APs) elicited by microtaps? Through rough qualitative estimations, some authors have suggested a positive answer to this question. However, in view of measurements performed in this investigation of both the density of mast cells and the diffusion coefficient of antigens, the probability of such mediated effects was found to be relatively low:P=0.016 for egg albumin andP=0.004 for ferritin. Therefore, most APs induced by microtaps should be attributed to the direct effect of antigen over the sensitized muscle fibers. Yet, both the density of mast cells found in this work and the known amount of histamine they are capable of releasing when challenged with antigen, support the hypothesis regarding the involvement of these cells when antigen is massively superfused so as to induce Schultz-Dale reactions in muscle strips. Under this circumstance, the direct and mediated mechanisms may coexist.
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Literature
Alonso-deFlorida, F., J. Del Castillo, X. García and E. Gijón. 1968. Mechanism of the Schultz-Dale reaction in the denervated diaphragmatic muscle of the guinea pig.J. Gen. Physiol. 51, 677–693.
Alonso-deFlorida, F., J. Del Castillo, C. González and V. Sánchez. 1965. On the pharmacological and anaphylactic responsiveness of denervated skeletal muscle of the guinea pig.Br. J. Pharmac. 25, 610–620.
Befus, A. D., F. L. Pearce, J. Gauldie and P. Horsewood. 1982. Mucosal mast cells. I. Isolation and functional characteristics of rat intestinal mast cells.J. Immunol. 128, 2475–2480.
Bull, H. B. 1941. Osmotic pressure of egg albumin solutions.J. biol. Chem. 137, 143–151.
Chand, N. and P. Eyre. 1978. The Schultz-Dale reaction: a review.Agents Actions 813, 171–184.
Crank, J. 1970.The Mathematics of Diffusion. Oxford: University Press.
Dale, M. M. and J. Zilleti. 1970. The Schultz-Dale response of the longitudinal muscle strip preparation of guinea-pig ileum.Br. J. Pharmac. 39, 542.
Einstein, A. 1956.Investigations on the Theory of the Brownian Movement. New York: Dover Publications Inc.
Guitiérrez-López, A. and F. Alonso-deFlorida. 1980. Isometric responses in the denervated diaphragmatic muscle of the guinea pig elicited by antigen and histamine.Acta physiol. Latinoamer.30, 259–268.
Ishizaka, T. and K. Ishizaka. 1984. Activation of mast cells for mediator release through IgE receptors.Prog. Allergy 34, 188–235.
Lichtenstein, L. M. 1968. Mechanism of allergic histamine release from human leukocytes. InBiochemistry of the Acute Allergic Reactions. K. F. Austen, and E. L. Becker (eds), pp. 153–174. Oxford: Blackwell Scientific.
Meyers, F. H., E. Jaweta and A. Goldfien. 1980.Review of Medical Pharmacology, Chapter 19. Los Altos, CA.
Munro, H. N. and M. C. Linder. 1978. Ferritin: structure, biosynthesis, and role in iron metabolism.Physiol. Rev. 58, 317–396.
Pearce, F. L., H. Behrendt, U. Blum, G. Poblete-Frudt, P. Pult and C. I. Stand-Voss. 1977. Isolation and study of functional mast cells from lung and mesentery of the guinea pig.Agents Actions 7, 45–56.
Sánchez-Mejorada, G. and F. Alonso-deFlorida. 1992. Changes in mast-cell distribution in skeletal muscle after denervation.Muscle Nerve 15, 716–719.
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Sánchez-Mejorada, G., Merchant-Larios, H., Alonso-deFlorida, F. et al. Probability of mast cells to mediate anaphylaxis in skeletal muscle. Bltn Mathcal Biology 56, 147–160 (1994). https://doi.org/10.1007/BF02458293
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DOI: https://doi.org/10.1007/BF02458293