Summary
This study confirms the importance of histologic tumor necrosis as a major prognostic variable in malignant glioma. Necrosis is present in glioblastoma multiforme (GBM), and absent in astrocytoma with atypical or anaplastic features (AAF). This paper evaluates 94 patients with AAF and 462 patients with GBM treated with radiation therapy with or without BCNU on 3 consecutive randomized protocols of the Radiation Therapy Oncology Group (RTOG) between 1974 and 1983. Multivariate analyses of the 556 patients confirmed histology as a significant independent variable that is prognostically relatively more important than Karnofsky performance status (KPS) and extent of surgery, and somewhat less important than age. The median survival for AAF was 36.2 months and for GBM was 8.6 months. In addition, separate multivariate analyses of AAf cases determined that the extent of surgery is a significant independent variable that is relatively more important than KPS, but less important than age. The median survival of AAF patients who underwent surgical excision was 46.8 months compared with 15.2 months for those biopsied (p < .001).
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Chang CH, Horton J, Schoenfeld D, Salazar O, Perez-Tamayo R, Kramer S, Weinstein A, Nelson JS, Tsukada Y: Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. Cancer 57: 997–1007, 1983.
Nelson JS, Tsudaka Y, Schoenfeld D, Fulling K, Lamarche J, and Peress N: Necrosis as a prognostic criterion in maligant supratentorial astrocytic gliomas. Cancer 52: 550–554, 1983.
Kaplan EL and Meier P: Non-parametric estimation from incomplete observations. J Am Statist Assoc 53: 457–481, 1958.
Mantel N: Evaluation of survival data and two new rank order statistics arising in its considerations. Cancer Chemotherapy Reports 50: 163–170, 1966.
Cox DR: Regression models and life tables. JR Statist Soc 34: 187–220, 1972.
Russel DC, Rubenstein LJ: Pathology of Tumors of the Nervous System (ed 4). Williams and Wilkins, Baltimore, 1977.
Burger PC, Vogel FS: Surgical Pathology of the Nervous System and its Coverings. John Wiley and Sons, New York, 1976.
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Nelson, D.F., Nelson, J.S., Davis, D.R. et al. Survival and prognosis of patients with astrocytoma with atypical or anaplastic features. J Neuro-Oncol 3, 99–103 (1985). https://doi.org/10.1007/BF02228884
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DOI: https://doi.org/10.1007/BF02228884