Journal of Autism and Developmental Disorders

, Volume 21, Issue 1, pp 51–59

Platelet serotonin, a possible marker for familial autism

Authors

  • Joseph Piven
    • Johns Hopkins University School of Medicine
  • Guochuan Tsai
    • Johns Hopkins University School of Medicine
  • Eileen Nehme
    • Johns Hopkins University School of Medicine
  • Joseph T. Coyle
    • Johns Hopkins University School of Medicine
  • Gary A. Chase
    • Johns Hopkins University School of Hygiene and Public Health
  • Susan E. Folstein
    • Johns Hopkins University School of Medicine
Article

DOI: 10.1007/BF02206997

Cite this article as:
Piven, J., Tsai, G., Nehme, E. et al. J Autism Dev Disord (1991) 21: 51. doi:10.1007/BF02206997

Abstract

Serotonin (5HT) levels in platelet-rich plasma were measured in 5 autistic subjects who had siblings with either autism or pervasive developmental disorder (PDD), 23 autistic subjects without affected siblings, and 10 normal controls. The 5HT levels of autistic subjects with affected siblings were significantly higher than probands without affected siblings, and autistic subjects without affected siblings had 5HT levels significantly higher than controls. Differences in 5HT levels remained significant after adjustment for sex, age, and IQ. These results suggest that 5HT level in autistic subjects may be associated with genetic liability to autism.

Copyright information

© Plenum Publishing Corporation 1991