Abstract
Changes in several characters of mycobacteriophage phlei B 2 were observed following its recovery from lysogenic complexes. These changes affected host range, immunity, plaque and electron microscopic morphology, antigenic composition, heat and U.V. sensitivity. It is suggested that the genetic mechanism by which multiple and reciprocal genetic changes in phage and mycobacterial host emerged is recombination rather than mutation.
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This research was supported by a Grant from the Medical Research Council of Canada.
Present address: Department of Microbiology, Loyola University of Chicago Stritch School of Medicine, and Veterans Administration Hospital, Hines, Illinois 60141, USA.
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Juhasz, S.E., Bönicke, R. Genetic interaction in mycobacterial host-phage systems the effect of lysogeny on the phage. Pneumologie 142, 181–190 (1970). https://doi.org/10.1007/BF02095214
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DOI: https://doi.org/10.1007/BF02095214