Skip to main content
SpringerLink
Log in

Studies on histamine release induced by compound 48/80 and peptide 401

  • European Branch of Histamine Club
  • Seventh Annual Meeting, May 2–4 1978, Łódź (Poland) Histamine Release
  • Published:
Agents and Actions Aims and scope Submit manuscript

Conclusion

The activity of the drugs under these conditions suggests that they, and possibly cyclic AMP, may have a wider role in regulating the intracellular concentration of calcium, whether derived from internal or external sources, or that they may have activities unrelated to calcium movements.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J.C. Foreman, M.B. Hallett andJ.L. Mongar,The Relationship between Histamine Secretion and 45 Calcium Uptake by Mast Cells, J. Physiol.271, 193–194 (1977).

    PubMed  Google Scholar 

  2. B. Uvnäs andI.-L. Thon,Evidence for Enzymatic Histamine Release from Isolated Rat Mast Cells, Exp. Cell Res.23, 45–57 (1961).

    Article  PubMed  Google Scholar 

  3. E.S.K. Assem andG. Atkinson,Histamine Release by MCDP (401), a Peptide from the Venom of the Honey Bee, Br. J. Pharmacol.48, 337P-338P (1973).

    PubMed  Google Scholar 

  4. L.J. Loeffler, W. Lovenberg andA. Sjoerdsma,Effects of Dibutyryl-3′-5′-cyclic Adenosine Monophosphate, Phosphodiesterase Inhibitors and Prostaglandin E 1 on Compound 48/80-Induced Histamine Release from Rat Peritoneal Mast Cells in vitro. Biochem. Pharmacol.20, 2287–2297 (1971).

    Article  PubMed  Google Scholar 

  5. W.W. Douglas andY. Ueda,Mast Cell Secretion (Histamine Release) Induced by 48-80: Calcium Dependent Exocytosis Inhibited Strongly by Cytochalasin only when Glycolysis is Rate-Limiting, J. Physiol.234, 97P-98P (1973).

    PubMed  Google Scholar 

  6. W.A. Taylor, D.H. Francis, D. Sheldon andI.M. Roit,The Anti-Anaphylactic Actions of Disodium Cromoglycate, Theophylline, and Prostaglandins, Int. Arch. Allergy,46, 104–120 (1974).

    PubMed  Google Scholar 

  7. J.C. Foreman, M.B. Hallett andJ.L. Mongar,Site of Action of the Antiallergic Drugs Cromoglycate and Doxantrazole, Br. J. Pharmacol.59, 473P-474P (1977).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, University College London, London, England

    F. L. Pearce & M. Ennis

  2. Department of Pharmacology, University College London, London, England

    G. Atkinson

Authors
  1. F. L. Pearce
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Atkinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Ennis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pearce, F.L., Atkinson, G. & Ennis, M. Studies on histamine release induced by compound 48/80 and peptide 401. Agents and Actions 9, 63–64 (1979). https://doi.org/10.1007/BF02024114

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02024114

Keywords

Search

Navigation