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Bone induction by lyophilized osteosarcoma in mice

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Abstract

Bone formation was induced by iso- and home-implantation of lyophilized mouse osteosarcoma, in which an osteogenic activity is observed. The inducing factor is present exclusively in osteosarcoma, such as BF and Gardner, while not in non-osteogenic tumors, such as Ehrlich ascites tumor (2N & 4N) or mouse mammary carcinoma. The production of bone was rapid and extensive. It usually occurred within 21 days, and the time required for osteogenesis was almost the same as that reported in previous studies.

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Authors and Affiliations

  1. Orthopedic Department, Osaka University Medical School, Fukushima-ku, Osaka, Japan

    Katsumasa Amitani, Yozo Nakata & Jack Stevens

  2. Cancer Research Institute, Osaka University Medical School, Fukushima-ku, Osaka, Japan

    Katsumasa Amitani, Yozo Nakata & Jack Stevens

Authors
  1. Katsumasa Amitani
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  2. Yozo Nakata
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  3. Jack Stevens
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Amitani, K., Nakata, Y. & Stevens, J. Bone induction by lyophilized osteosarcoma in mice. Calc. Tis Res. 16, 305–313 (1974). https://doi.org/10.1007/BF02008238

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  • DOI: https://doi.org/10.1007/BF02008238

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