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Studies on muscle fibre splitting in skeletal muscle

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Summary

Autoradiographic, stereological and histological studies have been carried out to determine the origin of muscle fibre splitting which supposedly occurs during muscle hypertrophy. The results obtained clearly indicate that the supposedly ‘split fibres’ are a transient response probably derived from satellite cells and are not derived from pre-existing fibres by true splitting. Similarly, increases in muscle fibre size are not achieved by recruitment of satellite structures as indicated by lack of myonuclear recruitment.

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Author information

Authors and Affiliations

  1. Department of Human Biology and Anatomy, University of Sheffield, S10 2TN, Sheffield, England

    G. W. Atherton, N. T. James & M. Mahon

  2. Department of Anatomy, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, England

    G. W. Atherton, N. T. James & M. Mahon

Authors
  1. G. W. Atherton
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  2. N. T. James
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  3. M. Mahon
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Additional information

Acknowledgment. This work was carried out with the aid of a grant from the Medical Research Council of Great Britain. The authors are grateful for the excellent technical assistance of Miss H. Caulton, M.J. Wild and M. Fenner.

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Atherton, G.W., James, N.T. & Mahon, M. Studies on muscle fibre splitting in skeletal muscle. Experientia 37, 308–310 (1981). https://doi.org/10.1007/BF01991672

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