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Myopathic changes at the end-plate region induced by neostigmine methylsulfate

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Summary

Administration of large dose of neostigmine caused very quickly marked myopathic changes at the motor end-plate region. With continued injections, however some recovery of the structural features did occur suggesting the reconstructive changes in the affected regions.

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Author notes

  1. M. Osame, S. Watanabe & A. Igata

    Present address: Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

Authors and Affiliations

  1. Department of Anatomy, Faculty of Medicine, Kyushu University, 2-1-1-Maidashi Higashi-ku, 812, Fukuoka, Japan

    M. Kawabuchi, M. Osame, S. Watanabe, A. Igata & T. Kanaseki

  2. Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

    M. Kawabuchi & T. Kanaseki

Authors
  1. M. Kawabuchi
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  2. M. Osame
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  3. S. Watanabe
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  4. A. Igata
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  5. T. Kanaseki
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Additional information

Acknowledgment. We wish to express our profound thanks to Dr.T. Iwayama and Ass. Prof.H. Ishikawa for their comments and discussions. Our thanks go also to Miss.R. Yokomine for her untiring technical assistance.

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Kawabuchi, M., Osame, M., Watanabe, S. et al. Myopathic changes at the end-plate region induced by neostigmine methylsulfate. Experientia 32, 623–625 (1976). https://doi.org/10.1007/BF01990200

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  • DOI: https://doi.org/10.1007/BF01990200

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