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Androstenedione or corticosterone treatment during pregnancy alters estrous cycle of adult female offspring in mice

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Female offspring from mice injected with androstenedione during late pregnancy showed lengthened vaginal cycles, persistent estrus and decreased incidence of pro-estrus and dïestrus, whilst offspring from mice injected with corticosterone showed increased incidence of dïestrus. These observations give qualified support to the hypothesis that stress during pregnancy alters the female offspring reproductive system through the action of adrenal steroids.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Keele, Keele, Staffordshire, England

    P. W. Harvey & P. F. D. Chevins

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  1. P. W. Harvey
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  2. P. F. D. Chevins
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Harvey, P.W., Chevins, P.F.D. Androstenedione or corticosterone treatment during pregnancy alters estrous cycle of adult female offspring in mice. Experientia 41, 492–494 (1985). https://doi.org/10.1007/BF01966165

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  • DOI: https://doi.org/10.1007/BF01966165

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