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Comparison of the immune response to sheep erythrocytes, tetanus toxoid and endotoxin in different strains of mice

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Abstract

The primary immune response in 7 inbred and 2 outbred mouse strains to SRBC, tetanus toxin and ‘E.coli’ endotoxin is compared. Significant variations are found in the different strains concerning their antibody response to these antigens. The differences in antibody production reached with SRBC (direct and indirect PFC) and tetanus toxin are on a quantitative level, those with endotoxin also on a qualitative level. The kinetic studies further indicate that course of antibody formation as well as peak of response may considerably vary between different strains.

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  1. Biological and Medical Research Division, Sandoz Ltd., CH-4002, Basle, Switzerland

    J. F. Borel

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Borel, J.F. Comparison of the immune response to sheep erythrocytes, tetanus toxoid and endotoxin in different strains of mice. Agents and Actions 4, 277–285 (1974). https://doi.org/10.1007/BF01965231

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