Summary
The systemic responses of different animals to a number of histamine liberators and the effects of these compounds on isolated tissue mast cells in vitro are examined. Mast cells from different species and even from individual tissues within a single animal are shown to vary markedly in their response to given inducers. On this basis, the usefulness of animal models in predicting whether a particular compound may act as a histamine liberator in man is discussed.
Zusammenfassung
Die körperlichen Reaktionen von verschiedenen Tieren auf mehrere Histaminliberatoren und die Wirkungen von diesen Substanzen an isolierten Gewebemastzellen in vitro sind untersucht worden. Mastzellen von verschiedenen Spezies und selbst von individuellen Geweben innerhalb eines einzelnen Tieres sind sehr unterschiedlich in ihrer Reaktion auf gegebene Liberatoren. Auf dieser Grundlage wird die Nützlichkeit in der Voraussage ob ein bestimmtes Mittel als Histaminliberator im Menschen wirken kann diskutiert.
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Pearce, F.L. Functional heterogeneity of mast cells from different species and tissues. Klin Wochenschr 60, 954–957 (1982). https://doi.org/10.1007/BF01716954
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DOI: https://doi.org/10.1007/BF01716954