Summary
Using a sensitive myoglobin-radioimmunoassay (Mb-RIA) serum Mb was measured in 50 patients with Duchenne muscular dystrophy (DMD) and compared with the serum creatine kinase (CK) activities. The Mb concentrations (normal range 4–60 ng/ml) measured ranged between 160–6,000 ng/ml and did not only show a significant correlation to the CK but also an inverse relationship to the age of the patients. It is suggested that Mb is an essential adjunct in the diagnosis of DMD.
Zusammenfassung
Mit einem empfindlichen Myoglobin-Radioimmunoassay (Mb-RIA) wurde bei 50 Patienten mit progressiver Muskeldystrophie vom Typ Duchenne (MDD) die Serum Mb-Konzentration gemessen und mit der Serum Kreatin Kinase (CK)-Aktivität verglichen. Die Mb-Konzentrationen (Normalbereich 4–60 ng/ml) bewegten sich zwischen 160–6000 ng/ml und ließen eine signifikante Korrelation zur CK und eine inverse Korrelation zum Alter der Patienten erkennen. Die Mb-Bestimmung im Serum kann somit als zusätzlicher Parameter bei der Diagnose der MDD herangezogen werden.
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Kießling, W.R., Beckmann, R. Serum levels of myoglobin and creatine kinase in duchenne muscular dystrophy. Klin Wochenschr 59, 347–348 (1981). https://doi.org/10.1007/BF01525003
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DOI: https://doi.org/10.1007/BF01525003