Summary
Serum cholesterol as risk factor for premature mortality; 0–6, mean 3 years after a screening investigation in 10,000 middle-aged men (46–48 years at screening) was studied with respect to category of death. Serum cholesterol was reciprocally correlated to cancer deaths and to alcohol-related deaths, and strongly positively correlated to deaths in coronary heart disease. The men who died of cancer did not have lower body weight, nor was there any association with serum triglycerides. The inverse correlation to serum cholesterol did not differ between the cancer deaths occuring early, and those occurring later after screening. Part of the cholesterol/cancer death relationship may be explained by the presence of an otherwise occult malignancy at screening, but it cannot be excluded that the development of some cancers may be associated with a state of low serum cholesterol.
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References
Beaglehole R, Foulkes MA, Prior IAM et al. (1980) Cholesterol and mortality in New Zealand Maoris. Br Med J I:285
Rose G, Shipley MJ (1980) Plasma lipids and mortality: a source of error. Lancet I:253
Petersson B, Trell E, Sternby NH (1981) Low cholesterol level as risk factor for noncoronary death in middle-aged men. JAMA 245:2056
Petersson B, Krantz P, Kristenson H, Trell E, Sternby N-H (1982) Alcohol-related death: A major contributor to mortality in urban middle-aged men. Lancet II:1088
Petersson B, Trell E, Krantz P, Sternby N-H, Hood B (1983) Major determinants of premature mortality in middle-aged urban males. Alcohol-related deaths, non-participation, and possible intervention effects in preventive population program directed against alcohol and its complications. (Submitted)
Kristensson H, Trell E, Hood B (1981) Serum gamma — glutamyltransferase in screening and continuous control if heavy drinking in middle-aged men. Am J Epidemiol 114:868
The Committe on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology (1976) Recommended method for the determination of gamma glutamyltransferase in blood. Scand J Clin Lab Invest 78:119
Maxwell AE (1961) Analyzing qualitative data. Methuen, London
Stamler J (1980) The established relationship among diet, serum cholesterol and coronary heart disease. Acta Med Scand 207:433
Ueshima H, Iida M, Shimamoto T et al. (1980) Multivariate analysis of risk factors for stroke. Prev Med 9:722
Kark JD, Smith AH, Hames CG (1980) The relationship of serum cholesterol to the incidence of cancer in Evans County, Georgia. J Chron Dis 33:311
Westlund K, Nicolaysen R (1972) Ten-year mortality and morbidity related to serum cholesterol. Scand J Lab Invest 30:[Suppl] 127
Williams RR, Sorlic PD, Feinlieb M et al. (1981) Cancer incidence by levels of cholesterol. JAMA 245:247
Cambien F, Ducimetriere P, Richard J (1980) Total serum cholesterol and cancer mortality in a middle-aged male population. Am J Epidemiol 112:388
Tartter PI, Papatestas AE, Ioannovich J (1981) Cholesterol and obesity as prognostic factors in breast cancer. Cancer 47:2222
Lannerstad O, Isacsson SO, Lindell SE (1979) Risk factors for premature death in men 56–60 years old. Scand J Soc Med 7:41
Böttiger LE, Carlsson LA (1980) Mortality and entry characteristics in the Stockholm Prospective Study. Skandia International Symposia: Medical aspects on mortality statistics, Stockholm, p 89
Singh V, Goyal RK, Mathur MN (1977) Serum cholesterol in patients with pulmonary tuberculosis. J Indian M 69:220
Oster P, Muchowski H, Heuck CC (1981) The prognostic significance of hypocholesterolemia in hospitalized patients. Klin Wochenschr 59:857
Gilbert HS, Ginsberg H, Fagerstrom R et al. (1981) Characterization of hypocholesterolemia in myeloproliferative disease. Relation to disease manifestations and activity. Am J Med 71:595
Inbar M, Shinitzky M (1974) Cholesterol as bioregulator in the development and inhibition of leukemia. Proc Natl Acad Sci USA 71:4229
Poikolainen K (1977) Alcohol poisoning mortality in four nordic countries. The Finnish foundation for alcohol studies
Grande F, Amatuzio DS (1960) The influence of ethanol on serum cholesterol concentration. Minnesota Med 11:731
Castelli WP, Gordon T, Hjortland MC et al. (1980) Alcohol and blood lipids. The Cooperative Lipoprotein Phenotyping Study. Lancet II:153
Kagan A, McGee DL, Yano K et al. (1981) Serum cholesterol and mortality in a Japanese — American population. Am J Epidem 114:11
Kozarevic D, McGee D, Vojvodic N et al. (1981) Serum cholesterol and mortality. The Yugoslavia Cardiovascular Disease Study. Am J Epidemiol 114:21
Garcia-Palmieri MR, Sorlie PD, Costas R et al. (1981) An apparent inverse relationship between serum cholesterol and cancer mortality in Puerto Rico. Am J Epidemiol 114:29
Dyer AR, Stamler J, Oglesby P et al. (1981) Serum cholesterol and risk of death from cancer and other causes in three Chicago epidemiological studies. J Chron Dis 34:249
International collaborative group (1982) Circulating cholesterol level and risk of death from Cancer in men aged 40 to 69 years. Experience of an international collaborative group. JAMA 248:2853
Petersson B, Trell E (1983) Raised serum urate concentration as risk factor for premature mortality in middle-aged men: relation to death from cancer. Br Med J 287:7
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This study was supported by the Swedish Council for planning and coordination of Research and by the Kristianstads County Council
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Peterson, B., Trell, E. Premature mortality in middle-aged men: Serum cholesterol as risk factor. Klin Wochenschr 61, 795–801 (1983). https://doi.org/10.1007/BF01496723
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DOI: https://doi.org/10.1007/BF01496723