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Autism and pervasive developmental disorders: Concepts and diagnostic issues

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Abstract

The purpose of this report is to bring up to date available information on the defining features and diagnostic issues relating to autism and related disorders. We review the validity of the syndrome based on our last review (Rutter, 1978; Schopler, 1978). Subsequent data have produced refinement in our understanding of both diagnostic criteria and the nature of the basic deficit. Controversies over both the boundaries and the heterogeneity within the autism syndrome are evaluated according to available evidence. Diagnostic rating instruments for expediting systematic sample selection are critiqued, and leads for new research directions are suggested.

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References

  • American Psychiatric Association. (1980).Diagnostic and statistical manual of mental disorders (DSM-III) (3rd ed.). Washington, D.C.: Author.

    Google Scholar 

  • Anwar, F. (1983). The role of sensory modality for the reproduction of shape by the severely retarded.British Journal of Developmental Psychology, 1, 317–328.

    Google Scholar 

  • August, G. J., & Lockhart, L. H. (1984). Familial autism and the fragile-X chromosome.Journal of Autism and Developmental Disorders, 14, 197–204.

    PubMed  Google Scholar 

  • August, G. J., Raz, N., Papanicolaon, A. C., Baird, T. D., Hirsch, S. L., & Hsu, L. L. (1984). Fenfluramine treatment in infantile autism: Neurochemical, electrophysiological, and behavioral effects.Journal of Nervous and Mental Disease, 172, 604–612.

    PubMed  Google Scholar 

  • August, G. J., Stewart, M. A., & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children.British Journal of Psychiatry, 138, 416–422.

    PubMed  Google Scholar 

  • Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a “theory of mind”?Cognition, 21, 37–46.

    PubMed  Google Scholar 

  • Bartak, L. (1978). Educational approaches. In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatment (pp. 423–438). New York: Plenum.

    Google Scholar 

  • Bartak, L., & Rutter, M. (1976). Differences between mentally retarded and normally intelligent autistic children.Journal of Autism and Childhood Schizophrenia, 6, 109–120.

    PubMed  Google Scholar 

  • Bartak, L., Rutter, M., & Cox, A. (1975). A comparative study of infantile autism and specific developmental receptive language disorder. I. The children.British Journal of Psychiatry, 126, 127–145.

    PubMed  Google Scholar 

  • Bauman, M., & Kemper, T. L. (1985). Histoanatomic observations of the brain in early infantile autism.Neurology, 35, 866–874.

    PubMed  Google Scholar 

  • Bender, L. (1947). Childhood schizophrenia. Clinical study of one hundred schizophrenic children.American Journal of Orthopsychiatry, 17, 40–56.

    Google Scholar 

  • Bettelheim, B. (1967).The empty fortress: Infantile autism and the birth of the self. New York: Free Press.

    Google Scholar 

  • Birch, H. G., Richardson, S. A., Baird, D., Horobin, G., & Illsley, R. (1970).Mental subnormality in the community: A clinical and epidemiological study. Baltimore: Williams & Wilkins.

    Google Scholar 

  • Blomquist, H. K., Bohman, M., Edvinsson, S. O., Gillberg, C., Gustavson, K-H., Holmgren, G., & Wahlstrom, J. (1984). Frequency of the fragile X syndrome in infantile autism: A Swedish multicenter study.Clinical Genetics, 27, 113–117.

    Google Scholar 

  • Blomquist, H. K., Gustavson, K-H., Holmgren, G., Nordenson, I., & Palsson-Strae, U. (1983). Fragile X syndrome in mildly mentally retarded children in a northern Swedish county. A prevalence study.Clinical Genetics, 24, 393–399.

    PubMed  Google Scholar 

  • Blomquist, H. K., Gustavson, K-H., Holmgren, G., Nordenson, I., & Sweins, A. (1982). Fragile site X-chromosomes and X-linked mental retardation in severely retarded boys in a northern Swedish county. A prevalence study.Clinical Genetics, 21, 209–214.

    PubMed  Google Scholar 

  • Boullin, D. J., Coleman, M., O'Brien, R. A., & Rimland, B. (1971). Laboratory predictions of infantile autism, based on 5-hydroxytryptamine efflux from blood platelets and their correlation with the Rimland E2 scores.Journal of Autism and Childhood Schizophrenia, 1, 63–71.

    PubMed  Google Scholar 

  • Boullin, D. J., Freeman, B. J., Geller, E., Ritvo, E., Rutter, M., & Yuwiler, A. (1982). Toward the resolution of conflicting findings [Letter to the editor].Journal of Autism and Developmental Disorders, 12, 97–98.

    Google Scholar 

  • Campbell, M. (1978). Pharmacotherapy. In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatment (pp. 337–355). New York: Plenum.

    Google Scholar 

  • Cantor, S., Evans, J., Pearce, J., & Pezzot-Pearce, T. (1982). Childhood schizophrenia: Present but not accounted for.American Journal of Psychiatry, 139, 758–762.

    PubMed  Google Scholar 

  • Cantwell, D., & Baker, L. (1985). Speech and language: Development and disorders. In M. Rutter & L. Hersov (Eds.),Child and adolescent psychiatry: Modern approaches (2nd ed.) (pp. 526–544).lOxford:Blackwell Scientific.

    Google Scholar 

  • Cantwell, D., Baker, L., Rutter, M., Mawhood, L. (1987).Comparative follow-up study of infantile autism and developmental receptive dysphasia. Manuscript submitted for publication.

  • Caparulo, B. K., Cohen, D. J., Young, G., Katz, J. D., Shaywitz, S. E., Shaywitz, B. A., & Rothman, S. L. (1981). Computed tomographic brain scanning in children with developmental neuropsychiatric disorders.Journal of the American Academy of Child Psychiatry, 20, 338–357.

    PubMed  Google Scholar 

  • Chess, S., Fernandez, P., & Korn, S. (1978). Behavioral consequences of congenital rubella.Journal of Pediatrics, 93, 699–703.

    PubMed  Google Scholar 

  • Chess, S., Korn, S. J., & Fernandez, P. E. (1971).Psychiatric disorders of children with congenital rubella. New York: Brunner/Mazel.

    Google Scholar 

  • Chick, J., Waterhouse, L., & Wolff, S. (1979). Psychological construing in schizoid children grown up.British Journal of Psychiatry, 135, 425–430.

    PubMed  Google Scholar 

  • Coleman, P. D., Romano, J., Lapham, L., & Simon, W. (1985). Cell counts in cerbral cortex of an autistic patient.Journal of Autism and Developmental Disorders, 15, 245–256.

    PubMed  Google Scholar 

  • Corbett, J. A. (1976). Medical management. In L. Wing (Ed.),Early childhood autism: Clinical, educational and social aspects (2nd ed.). Oxford: Pergamon.

    Google Scholar 

  • Corbett, J., Harris, R., Taylor, E., & Trimble, M. (1977). Progressive disintegrative psychosis of childhood.Journal of Child Psychology and Psychiatry, 18, 211–219.

    PubMed  Google Scholar 

  • Creak, M. (1963). Childhood psychosis: A review of 100 cases.British Journal of Psychiatry, 109, 84–89.

    PubMed  Google Scholar 

  • Curtiss, S. (1977).Genie: A psycholinguistic study of a modern-day “Wild Child.” London: Academic Press.

    Google Scholar 

  • Damasio, H., Maurer, R. G., Damasio, A. R., & Chui, H. C. (1980). Computerized tomographic scan findings in patients with autistic behavior.Archives of Neurology, 37, 504–510.

    PubMed  Google Scholar 

  • Darby, J. K. (1976). Neuropathologic aspects of psychosis in childhood.Journal of Autism and Childhood Schizophrenia, 6, 339–352.

    PubMed  Google Scholar 

  • Dawson, G. (1983). Lateralized brain function in autism: Evidence from the Halstead-Reitan neuropsychological battery.Journal of Autism and Developmental Disorders, 13, 369–386.

    Google Scholar 

  • De Sanctis, S. (1906). On some varieties of dementia praecox.Riv. Sper. Freniatr., 32, 141–165. (Translated and reprinted in J. G. Howells (Ed.),Modern perspectives in international child psychiatry. Edinburgh: Oliver & Boyd, 1969.)

    Google Scholar 

  • Deykin, E. Y., & MacMahon, D. (1979). The incidence of seizures among children with autistic symptoms.American Journal of Psychiatry, 136, 1310–1312.

    PubMed  Google Scholar 

  • Deykin, E. Y., & MacMahon, B. (1980). Pregnancy, delivery and neonatal complications among autistic children.American Journal of Diseases of Children, 134, 860–864.

    PubMed  Google Scholar 

  • Eggers, C. (1978). Course and prognosis of childhood schizophrenia.Journal of Autism and Childhood Schizophrenia, 8, 21–36.

    PubMed  Google Scholar 

  • Eisenberg, L. (1956). The autistic child in adolescence.American Journal of Psychiatry, 112, 607–612.

    PubMed  Google Scholar 

  • Eisenberg, L. (1972). The classification of childhood psychosis reconsidered.Journal of Autism and Childhood Schizophrenia, 2, 338–342.

    PubMed  Google Scholar 

  • Evans-Jones, L. G., & Rosenbloom, L. (1978). Disintegrative psychosis in childhood.Developmental Medicine and Child Neurology, 20, 462–470.

    PubMed  Google Scholar 

  • Fein, D., Skoff, B., & Mirsky, A. F. (1981). Clinical correlates of brainstem dysfunction in autistic children.Journal of Autism and Developmental Disorders, 11, 303–316.

    PubMed  Google Scholar 

  • Ferrari, M., & Matthews, W. S. (1983). Self-recognition deficits in autism: Syndrome-specific or general developmental delay?Journal of Autism and Developmental Disorders, 13, 317–324.

    PubMed  Google Scholar 

  • Finegan, J., & Quadrington, B. (1979). Pre-, peri-, and neonatal factors and infantile autism.Journal of Child Psychology and Psychiatry, 20, 119–128.

    PubMed  Google Scholar 

  • Folstein, S., and Rutter, M. (in press). Autism: familial aggregation and genetic implications.Journal of Autism and Developmental Disorders.

  • Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs.Journal of Child Psychology and Psychiatry, 18, 297–321.

    PubMed  Google Scholar 

  • Freeman, B. J., Ritvo, E. R., Guthrie, D., Schroth, P., & Ball, J. (1978). The Behavior Observation Scale for Autism: Initial methodology, data analysis, and preliminary findings on 89 children.Journal of the American Academy of Child Psychiatry, 17, 576–588.

    PubMed  Google Scholar 

  • Freeman, B. J., Ritvo, E. R., & Schroth, P. C. (1984). Behavior assessment of the syndrome of autism: Behavior Observation System.Journal of the American Academy of Child Psychiatry, 23, 588–594.

    PubMed  Google Scholar 

  • Frith, U. (1971). Spontaneous patterns produced by autistic, normal and subnormal children. In M. Rutter (Ed.),Infantile autism: Concepts, characteristics and treatment (pp. 113–131). Edinburgh and London: Churchill-Livingston.

    Google Scholar 

  • Fyffe, C., & Prior, M. R. (1978). Evidence of language recoding in autistic children: A reexamination.British Journal of Psychiatry, 69, 393–403.

    Google Scholar 

  • Geller, E., Ritvo, E. R., Freeman, B. J., & Yuwiler, A. (1982). Preliminary observations of the effect of fenfluramine on blood serotonin and symptoms in three autistic boys.New England Journal of Medicine, 307, 165–169.

    PubMed  Google Scholar 

  • Gillberg, C. (1983). Identical triplets with infantile autism and the fragile-X syndrome.British Journal of Psychiatry, 143, 256–260.

    PubMed  Google Scholar 

  • Gillberg, C., & Forsell, C. (1984). Childhood psychosis and neurofibromatosis-More than a coincidence?Journal of Autism and Developmental Disorders, 14, 1–8.

    PubMed  Google Scholar 

  • Gillberg, C., & Gillberg, I. C. (1983). Infantile autism: A total population study of nonoptimal, pre-, peri-, and neonatal conditions.Journal of Autism and Developmental Disorders, 13, 153–166.

    PubMed  Google Scholar 

  • Gillberg, C., & Schaumann, H. (1981). Infantile autism and puberty.Journal of Autism and Developmental Disorders, 11, 365–371.

    PubMed  Google Scholar 

  • Gillberg, C., & Svendsen, P. (1983). Childhood psychosis and computed tomographic brain scan findings.Journal of Autism and Developmental Disorders, 13, 19–32.

    PubMed  Google Scholar 

  • Goldfine, P. E., McPherson, P. M., Heath, G. A., Hardesty, V. A., Beauregard, L. J., & Gordon, S. (1985). Association of fragile X syndrome with autism.American Journal of Psychiatry, 142, 108–110.

    PubMed  Google Scholar 

  • Green, W. H., Campbell, M., Hardesty, A. S., Grega, D. M., Padron-Gayol, M., Shell, J., & Erlenmeyer-Kimling, L. (1984). A comparison of schizophrenic and autistic children.Journal of the American Academy of Child Psychiatry, 23, 399–409.

    PubMed  Google Scholar 

  • Hagberg, B., Aicardi, J., Dias, K., & Ramos, O. (1983). A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: Report of 35 cases.Annals of Neruology, 14, 471–479.

    Google Scholar 

  • Heller, T. (1930). About dementia infantilis. (Reprinted in J. G. Howells (Ed.),Modern perspectives in international child psychiatry. Edinburgh: Oliver & Boyd, 1969).

  • Hemsley, R., Howlin, P., Berger, M., Hersov, L., Holbrook, D., Rutter, M., & Yule, W. (1978). Training autistic children in a family context. In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatment (pp. 378–411). New York: Plenum.

    Google Scholar 

  • Hermelin, B., & O'Connor, N. (1970).Psychological experiments with autistic children. Oxford: Pergamon.

    Google Scholar 

  • Herold, S., Frackowiak, R. S. J., Rutter, M., & Howlin, P. (in press). Regional cerebral blood flow, oxygen and glucose metabolism in young autistic adults.Journal Cerebral Blood Flow and Metabolism.

  • Hobson, R. P. (1983). The autistic child's recognition of age-related features of people, animals and things.British Journal of Developmental Psychology, 4, 343–352.

    Google Scholar 

  • Hobson, R. P. (1985).The autistic child's appraisal of expressions of emotion: An experimental investigation. Manuscript submitted for publication.

  • Howells, J. G., & Guirguis, W. R. (1984). Childhood schizophrenia 20 years later.Archives of General Psychiatry, 41, 123–128.

    PubMed  Google Scholar 

  • Howlin, P., & Rutter, M. (in press).Autistic children and their families: Approaches to treatment. Chichester: Wiley.

  • James, A. L., & Barry, R. J. (1980). A review of psychophysiology in early onset psychosis.Schizophrenia Bulletin, 6, 506–525.

    PubMed  Google Scholar 

  • James, A. L., & Barry, R. J. (1983). Developmental effects in the cerebral lateralization of autistic, retarded, and normal children.Journal of Autism and Developmental Disorders, 13, 43–56.

    PubMed  Google Scholar 

  • Kanner, L. (1943). Autistic disturbances of affective contact.Nervous Child, 2, 217–230.

    Google Scholar 

  • Kanner, L. (1973).Childhood psychosis: Initial studies and new insights. Washington, D.C.: Winston.

    Google Scholar 

  • Kolvin, I. (1971). Psychoses in childhood—A comparative study. In M. Rutter (Ed.),Infantile autism: Concepts, characteristics and treatment (pp. 7–26). London: Churchill-Livingstone.

    Google Scholar 

  • Kolvin, I. (1974). Research into childhood psychoses: A crosscultural comparison and commentary.International Journal of Mental Health, 2, 194–212.

    Google Scholar 

  • Krug, D. A., Arick, J. R., & Almond, P. J. (1980). Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior.Journal of Child Psychology and Psychiatry, 21, 221–229.

    PubMed  Google Scholar 

  • Kydd, R. R., & Werry, J. S. (1982). Schizophrenia in children under 16 years.Journal of Autism and Developmental Disorders, 12, 343–358.

    PubMed  Google Scholar 

  • Largo, R. H., & Schinzel, A. (1985). Developmental and behavioural disturbances in 13 boys with fragile X syndrome.European Journal of Pediatrics, 143, 269–275.

    PubMed  Google Scholar 

  • Levitas, A., Hagerman, R. J., Braden, M., Rimland, B., McBog, P., & Matteus, I. (1983). Autism and fragile X syndrome.Journal of Developmental and Behavioural Pediatrics, 3, 151–158.

    Google Scholar 

  • Lord, C., Schopler, E., & Revick, D. (1982). Sex differences in autism.Journal of Autism and Developmental Disorders, 12, 317–330.

    PubMed  Google Scholar 

  • Lotter, V. (1974). Factors related to outcome in autistic children.Journal of Autism and Childhood Schizophrenia, 4, 263–277.

    PubMed  Google Scholar 

  • Makita, K. (1974). What is this thing called childhood schizophrenia?International Journal of Mental Health, 2, 179–193.

    Google Scholar 

  • Malamud, N. (1959). Heller's disease and childhood schizophrenia.American Journal of Psychiatry, 116, 215–218.

    PubMed  Google Scholar 

  • Maudsley, H. (1867).The physiology and pathology of the mind. London: Macmillan.

    Google Scholar 

  • Mrazek, D., & Mrazek, P. (1985). Child maltreatment. In M. Rutter & L. Hersov (Eds.),Child and adolescent psychiatry: Modern approaches (2nd ed., pp. 698–719). Oxford: Blackwell Scientific.

    Google Scholar 

  • Novic, J., Luchins, D. J., & Perline, R. (1984). Facial affect recognition in schizophrenia: Is there a differential deficit?British Journal of Psychiatry, 144, 533–537.

    PubMed  Google Scholar 

  • Novick, B., Kurtzberg, D., & Vaughn, H. G. (1979). An electrophysiologic indication of defective informate storage in childhood autism.Psychiatric Research, 1, 101–198.

    Google Scholar 

  • Ornitz, E. M. (1978). Neurophysiologic studies. In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatment (pp. 117–139). New York: Plenum.

    Google Scholar 

  • Parks, S. L. (1983). The assessment of autistic children: A selective review of available instruments.Journal of Autism and Developmental Disorders, 13, 255–267.

    PubMed  Google Scholar 

  • Paul, R., & Cohen, D. J. (1984). Outcomes of severe disorders of language acquisition.Journal of Autism and Developmental Disorders, 14, 405–422.

    PubMed  Google Scholar 

  • Paul, R., Cohen, D. J., & Caparulo, B. K. (1983). A longitudinal study of patients with severe developmental disorders of language learning.Journal of the American Academy of Child Psychiatry, 22, 525–534.

    PubMed  Google Scholar 

  • Petty, L., Ornitz, E. M., Michelman, J. D., & Zimmerman, E. G. (1984). Autistic children who become schizophrenic.Archives of General Psychiatry, 41, 129–135.

    PubMed  Google Scholar 

  • Prior, M. R., Tress, B., Hoffman, W. L., & Boldt, D. (1984). Computed tomographic study of children with classic autism.Archives of Neurology, 41, 482–484.

    PubMed  Google Scholar 

  • Pueschel, S. M., Herman, R., & Groden, G. (1985). Brief report: Screening children with autism for fragile-X syndrome and phenylketonuria.Journal of Autism and Developmental Disorders, 15, 335–338.

    PubMed  Google Scholar 

  • Richardson, S. A., Koller, H., Katz, M., & McLaren, J. (1980). Seizures and epilepsy in a mentally retarded population over the first 22 years of life.Applied Research in Mental Retardation, 1, 123–138.

    PubMed  Google Scholar 

  • Riikonen, R., & Amnell, G. (1981). Psychiatric disorders in children with earlier infantile spasms.Developmental Medicine and Child Neurology, 23, 747–760.

    PubMed  Google Scholar 

  • Rimland, B. (1971). The differentiation of childhood psychoses: An analysis of checklists for 2,218 psychotic children.Journal of Autism and Childhood Schizophrenia, 1, 161–174.

    PubMed  Google Scholar 

  • Rimland, B. (1984). Diagnostic checklist form E2: A reply to Parks.Journal of Autism and Developmental Disorders, 14, 343–345.

    PubMed  Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Geller, E., & Yuwiler, A. (1983). Effects of fenfluramine on 14 outpatients with the syndrome of autism.Journal of the American Academy of Child Psychiatry, 22, 549–558.

    PubMed  Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., & Ritvo, A. M. (1985). Concordance for the syndrome of autism in 40 pairs of afflicted twins.American Journal of Psychiatry, 142, 74–77.

    PubMed  Google Scholar 

  • Ritvo, E. R., Spence, M. A., Freeman, B. J., Mason-Brothers, A., Mo, A., & Marazita, M. L. (1985). Evidence for autosomal recessive inheritance in 46 families with multiple incidences of autism.American Journal of Psychiatry, 142, 187–191.

    PubMed  Google Scholar 

  • Rosenbloom, S., Campbell, M., George, A. E., Kricheff, I., Taleporos, E., Anderson, L., Reuben, R. N., & Korein, J. (1984). High resolution CT scanning in infantile autism: A quantitative approach.Journal of the American Academy of Child Psychiatry, 23, 72–77.

    PubMed  Google Scholar 

  • Rosenblum, S. M., Arick, J. R., Krug, D. A., Stubbs, E. G., Young, N. B., & Pelson, R. O. (1980). Auditory brainstem-evoked responses in autistic children.Journal of Autism and Developmental Disorders, 10, 215–226.

    PubMed  Google Scholar 

  • Rumsey, J. M., Duara, R., Grady, C., Rapoport, J. L., Margolin, R. A., Rapoport, S. I., & Cutler, N. R. (1985). Brain metabolism in autism: Resting cerebral glucose utilization as measured with positron emission tomography (PET).Archives of General Psychiatry, 15, 448–457.

    Google Scholar 

  • Rumsey, J., Schwartz, M., Creasey, H., Dwana, R., Rapoport, J. L., Rapoport, S. I., & Cutler, N. R. (1983).Quantitative CT-scan findings in autism Unpublished manuscript, American Psychological Association, Arnheim, California, August 26–30.

    Google Scholar 

  • Ruttenberg, B. A., Dratman, M. L., Fraknoi, J., & Wenar, C. (1966). An instrument for evaluating autistic children.Journal of the American Academy of Child Psychiatry, 5, 453–478.

    PubMed  Google Scholar 

  • Rutter, M. (1970). Autistic children: Infancy to adulthood.Seminars in Psychiatry, 2, 435–450.

    PubMed  Google Scholar 

  • Rutter, M. (1972). Childhood schizophrenia reconsidered.Journal of Autism and Childhood Schizophrenia, 2, 315–337.

    PubMed  Google Scholar 

  • Rutter, M. (1974). The development of infantile autism.Psychological Medicine, 4, 147–163.

    PubMed  Google Scholar 

  • Rutter, M. (1978). Diagnosis and definition of childhood autism.Journal of Autism and Childhood Schizophrenia, 8, 139–161.

    PubMed  Google Scholar 

  • Rutter, M. (1979). Language, cognition and autism. In R. Katzman (Ed.),Congenital and acquired cognitive disorders. New York: Raven Press.

    Google Scholar 

  • Rutter, M. (1981).Maternal deprivation reassessed. Harmondsworth, Middlesex: Penguin.

    Google Scholar 

  • Rutter, M. (1983). Cognitive deficits in the pathogenesis of autism.Journal of Child Psychology and Psychiatry, 24, 513–531.

    PubMed  Google Scholar 

  • Rutter, M. (1984). Infantile autism. In D. Shaffer, A. Erhardt, & L. Greenhill (Eds.),A clinician's guide to child psychiatry (pp. 48–78). New York: Free Press.

    Google Scholar 

  • Rutter, M. (1985a). Infantile autism and other pervasive developmental disorders. In M. Rutter & L. Hersov (Eds.),Child and adolescent psychiatry: Modern approaches (pp. 545–564). Oxford: Blackwell Scientific.

    Google Scholar 

  • Rutter, M. (1985b). The treatment of autistic children.Journal of Child Psychology and Psychiatry, 26, 193–214.

    PubMed  Google Scholar 

  • Rutter, M., & Garmezy, N. (1983). Developmental psychopathology. In E. M. Hetherington (Ed.),Socialization, personality, and social development, Vol. 4, Mussen's handbook of child psychology (4th ed., pp. 775–911). New York: Wiley.

    Google Scholar 

  • Rutter, M., & Gould, M. (1985). Classification. In M. Rutter & L. Hersov (Eds.),Child and adolescent psychiatry: Modern approaches (pp. 304–321). Oxford: Blackwell Scientific.

    Google Scholar 

  • Schopler, E. (1978). Diagnosis and definition of autism.Journal of Autism and Childhood Schizophrenia, 8, 167–169.

    Google Scholar 

  • Schopler, E. (1983). New developments in the definition and diagnosis of autism. In B. B. Lahey & A. E. Kazdin (Eds.),Advances in clinical child psychology (Vol. 6, pp. 93–127). New York: Plenum.

    Google Scholar 

  • Schopler, E., Mesibov, G., & Baker, A. (1982). Evaluation of treatment for autistic children and their parents.Journal of the American Academy of Child Psychiatry, 21, 262–267.

    PubMed  Google Scholar 

  • Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980). Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS).Journal of Autism and Developmental Disorders, 10, 91–103.

    PubMed  Google Scholar 

  • Schopler, E., Reichler, R. J., & Renner, B. R. (1985).Childhood Autism Rating Scale (CARS). New York: Irvington.

    Google Scholar 

  • Schopler, E., & Rutter, M. (1978). Subgroups vary with selection purpose. In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatment (pp. 507–517). New York: Plenum.

    Google Scholar 

  • Scott, D. W. (1985). Asperger's syndrome and non-verbal communications: a pilot study.Psychological Medicine, 15, 683–687.

    PubMed  Google Scholar 

  • Skoff, B. F., Mirsky, A. F., & Turner, D. (1980). Prolonged brain-stem transmission time in autism.Psychiatric Research, 2, 157–166.

    Google Scholar 

  • Skuse, D. (1984). Extreme deprivation in early chilodhood: I. Diverse outcomes for three siblings from an extraordinary family.Journal of Child Psychology and Psychiatry, 26, 523–541.

    Google Scholar 

  • Spence, M. A., Ritvo, E. R., Marazita, M. L., Funderburk, S. J., Sparkes, R. S., & Freeman, B. J. (1985). Gene mapping studies with the syndrome of autism.Behavior Genetics, 15, 1–13.

    PubMed  Google Scholar 

  • Spiker, D., & Ricks, M. (1984). Developmental relationships in self-recognition: A study of 52 autistic children.Child Development, 55, 214–225.

    PubMed  Google Scholar 

  • Taft, L. T., & Cohen, H. J. (1971). Hypsarrhythmia and infantile autism: A clinical report.Journal of Autism and Childhood Schizophrenia, 1, 327–336.

    PubMed  Google Scholar 

  • Tanguay, P. E. (1984). Toward a new classification of serious psychopathology in children.Journal of the American Academy of Child Psychiatry, 23, 373–384.

    PubMed  Google Scholar 

  • Torrey, E. F., Hersh, S. P., & McCabe, K. D. (1975). Early childhood psychosis and bleeding during pregnancy.Journal of Autism and Childhood Schizophrenia, 5, 287–297.

    PubMed  Google Scholar 

  • Tinbergen, N., & Tinbergen, E. A. (1983). “Autisticchildren”: New hope for a cure. London: Allen & Unwin.

    Google Scholar 

  • Tsai, L., Stewart, M. A., & August, G. (1981). Implication of sex differences in the familial transmission of infantile autism.Journal of Autism and Developmental Disorders, 11, 165–173.

    PubMed  Google Scholar 

  • Venter, P. A., Hof, J. O., Coetzee, D. J., Van der Walt, C., & Retief, A. E. (1984). No marker (X) syndrome in autistic children.Human Genetics, 67, 107.

    PubMed  Google Scholar 

  • Walker, E., Bettes, B., & McGuire, M. (1984). Recognition and identification of facial stimuli by schizophrenics and patients with affective disorder.British Journal of Clinical Psychology, 23, 37–44.

    PubMed  Google Scholar 

  • Watson, M. S., Leckman, J. F., Annex, B., Breg, W. R., Boles, D., Volkmar, F. R., Cohen, D. J., & Carter, C. (1984). Fragile X in a survey of 75 autistic males.New England Journal of Medicine, 310, 1462.

    Google Scholar 

  • Williams, R. S., Hauser, S. L., Purpura, D., Delong, R., & Swisher, C. N. (1980). Autism and mental retardation: Neuropathological studies performed in four retarded persons with autistic behavior.Archives of Neurology, 37, 749–753.

    PubMed  Google Scholar 

  • Wing, L. (1981). Language, social, and cognitive impairments in autism and severe mental retardation.Journal of Autism and Developmental Disorders, 11, 31–44.

    PubMed  Google Scholar 

  • Wing, L., & Gould, J. (1978). Systematic recording of behaviors and skills of retarded and psychotic children.Journal of Autism and Childhood Schizophrenia, 8, 79–97.

    PubMed  Google Scholar 

  • Wing, L., & Gould, J. (1979). Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification.Journal of Autism and Developmental Disorders, 9, 11–30.

    PubMed  Google Scholar 

  • Wolff, S., & Barlow, A. (1979). Schizoid personality in childhood. A comparative study of schizoid, autistic and normal children.Journal of Child Psychology and Psychiatry, 20, 19–46.

    Google Scholar 

  • Wolff, S., & Chick, J. (1980). Schizoid personality in childhood: A controlled follow-up study.Psychological Medicine, 10, 85–100.

    PubMed  Google Scholar 

  • World Health Organization (1978).International classification of diseases. Geneva: Author.

    Google Scholar 

  • Yule, W. (1978). Research methodology: What are the “correct controls”? In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatment (pp. 155–162). New York: Plenum.

    Google Scholar 

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This paper was originally prepared for an NIMH Research Workshop to examine research issues in relation to the assessment, diagnosis, and classification of child and adolescent psychiatric disorders. Adapted with permission from M. Rutter, A. H. Tuma, & I. Lann,The Assessment and Diagnosis of Child and Adolescent Psychology, Guilford Press, New York, in press.

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Rutter, M., Schopler, E. Autism and pervasive developmental disorders: Concepts and diagnostic issues. J Autism Dev Disord 17, 159–186 (1987). https://doi.org/10.1007/BF01495054

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