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Counteraction of cyanide poisoning by thiosulphate when administering sodium nitroprusside as a hypotensive treatment

Zyanid-Entgiftung mit Thiosulfat bei der hypotensiven Therapie mit Natriumnitroprussid

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Zusammenfassung

Ein 42jähriger Patient bekam etwa 4 Tage lang Natriumnitroprussid (NNP) mit einem Dosisstrom von 600 µg/min infundiert. Am dritten Behandlungstag wurde ein gefährlich erhöhter Zyanidspiegel im Blut gemessen. Unter der zusätzlichen Infusion von Natriumthiosulfat in 5fachem molaren Überschuß sank dieser Spiegel in 7 h auf 1/7 des Ausgangswertes. Das Thiosulfat beeinträchtigte die blutdrucksenkende Wirkung des NNP nicht.

Summary

A 42-year old patient received a continuous infusion of sodium nitroprusside (SNP) at a dosage rate of 600 µg/min for approximately four days. On the third day of treatment a dangerous high level of cyanide was measured in the blood. When an additional continuous infusion of sodium thiosulphate at five times the molar concentration of the SNP was given, this cyanide level dropped over a period of 7 h to one-seventh of its initial value. The thiosulphate did not reduce the effectiveness of the SNP in lowering the blood pressure.

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Authors and Affiliations

  1. University of Cologne Medical Clinic, Germany

    V. Schulz

  2. Pharma Schwarz GmbH, Monheim

    R. Bonn

  3. Institute of Anaesthetics, University of Cologne, Germany

    H. Kämmerer, R. Kriegel & N. Ecker

Authors
  1. V. Schulz
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  2. R. Bonn
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  3. H. Kämmerer
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  4. R. Kriegel
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  5. N. Ecker
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Schulz, V., Bonn, R., Kämmerer, H. et al. Counteraction of cyanide poisoning by thiosulphate when administering sodium nitroprusside as a hypotensive treatment. Klin Wochenschr 57, 905–907 (1979). https://doi.org/10.1007/BF01477029

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  • DOI: https://doi.org/10.1007/BF01477029

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