Summary
Concurrent and consecutive infection or immunisation with yellow fever virus and UGMP-359 virus was investigated in mice, using identical doses of both viruses. In double infection it was shown that both viruses could multiply independently of one another, when both were inoculated simultaneously by the intracerebral route. On the other hand, there was mutual exclusion between them when the inoculation of one antedated the other, by the same intracerebral route. Both viruses multiplied to similar titres, in single infection, in the target organ (brain). By the intraperitoneal route, the outcome was influenced by the relative sensitivity of this route of inoculation to support and sustain the replication of either virus. Thus, because yellow fever virus replicated more than UGMP-359 after intraperitoneal inoculation, the latter is always excluded, even when the inoculation of UGMP-359 preceded that of yellow fever.
In the double immunization studies it was shown that comparative specific antibody titres to both viruses were obtained either when both viruses, as immunogens, were given simultaneously, or when the inoculation of one was alternated, at weekly intervals, with the other.
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References
Andrewes, C. H.: Interference by one virus with the growth of another in tissue culture. Brit. J. exp. Path.23, 214–220 (1942).
Andrewes, C. H., Elford, W. J.: Infectious ectromelia: experiments on interference and immunization. Brit. J. exp. Path.28, 278–285 (1947).
Burnet, F. M.: Interference between viruses and other aspects of intracellular replication. In: Principles of Animal Virology, 2nd ed., chap. 8. New York: Academic Press, 1960.
David-West, T. S.: New Simbu viruses: Antigenic analysis by complement fixation and immunodiffusion tests. Indian J. med. Res.60, 191–199 (1972).
Delbrück, M.: Interference between bacterial viruses. III. The mutual exclusion effect and the depressor effect. J. Bact.50, 151–170 (1945).
Delbrück, M., Luria, S. E.: Interference between bacterial viruses. I. Interference between two bacterial viruses acting upon the same host, and the mechanism of virus growth. Arch. Biochem.1, 111–141 (1942).
Finlay, G. M., MacCallum, F. O.: An interference phenomenon in relation to yellow fever and other viruses. J. Path. Bact.44, 405–424 (1937).
Finlay, G. M., Howard, E. M.: Virus exaltation. Brit. J. exp. Path.31, 45–50 (1950).
Henle, W.: Interference phenomena between animal viruses: A Review. J. Immunol.64, 203–236 (1950).
Hoskins, M.: A protective action of neurotropic against viscerotropic yellow fever virus in Macacus Rhesus. Amer. J. trop. Med.15, 675–680 (1935).
Kassanis, B.: Interactions of viruses in plants. Advanc. Virus Res.10, 219–255 (1963).
Luria, S. E.: Interference phenomena in virus infections. In: General Virology, 3rd ed., chap. 14. New York: J. Wiley, 1959.
Price, W. C.: Acquired immunity from plant virus diseases. Quart. Rev. Biol.15, 338–361 (1940).
Tikasingh, E. L., Spence, L., Downs, W. G.: The use of adjuvants and sarcoma 180 cells in the production of mouse hyperimmune ascitic fluids to arboviruses. Amer. J. trop. Med. Hyg.15, 219–226 (1966).
Tomori, O., Fabiyi, A., Bayomi, E.: Serological evidence demonstrating a concurrent infection by yellow fever and UGMP-359 viruses at Mabudi Benue Plateau State. Abstract: Nigerian Soc. Immunol. Annual gen. Meeting and scientific Session. p. 14. (1974.)
Weinbren, M.: An improved method for the complement fixation test using small quantities of reagents. East Afr. Virus Res. Inst. Rep.8, 38 (1958).
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David-West, T.S. Concurrent and consecutive infection and immunisation with yellow fever and UGMP-359 viruses. Archives of Virology 48, 21–28 (1975). https://doi.org/10.1007/BF01320562
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DOI: https://doi.org/10.1007/BF01320562