Original Papers

Journal of Neural Transmission

, Volume 64, Issue 3, pp 285-293

Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockersin vitro

  • W. IliasAffiliated withL. Boltzmann-Institut für Experimentelle Anaesthesiologie und Intensivmedizinische Forschung, Klinik für Anaesthesie und Allgemeine Intensivmedizin der Universität Wien
  • , K. SteinbereithnerAffiliated withL. Boltzmann-Institut für Experimentelle Anaesthesiologie und Intensivmedizinische Forschung, Klinik für Anaesthesie und Allgemeine Intensivmedizin der Universität Wien

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Summary

The calcium channel blockers verapamil, methoxyverapamil, diltiazem, and nisoldipine have been tested for interactions with the nondepolarizing muscle relaxant pancuronium bromide by using the indirectly stimulatedin vitro preparation of the rat hemidiaphragm. Dose response curves of each calcium channel blocker, pancuronium bromide, and combinations of both were determined.

Each of the four calcium channel blocking drugs showed agonistic interaction in potentiating pancuronium induced neuromuscular blockade.