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Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockersin vitro

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Summary

The calcium channel blockers verapamil, methoxyverapamil, diltiazem, and nisoldipine have been tested for interactions with the nondepolarizing muscle relaxant pancuronium bromide by using the indirectly stimulatedin vitro preparation of the rat hemidiaphragm. Dose response curves of each calcium channel blocker, pancuronium bromide, and combinations of both were determined.

Each of the four calcium channel blocking drugs showed agonistic interaction in potentiating pancuronium induced neuromuscular blockade.

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References

  • Bikhazi, G. B., Thomas, K. C., Foldes, F. F.: Effects of verapamil on mammalian musclein vitro. Anesthesiology51, 3-S275 (1979).

    Google Scholar 

  • Colvin, R. A., Pearson, N., Messineo, F. C., Katz, A. M.: Effects of Ca-channel blockers on Ca transport and ATPase in skeletal and cardiac sarcoplasmic reticulum vesicles. J. Cardiovasc. Pharm.4, 935–941 (1982).

    Google Scholar 

  • Durant, N. N., Nguyen, N., Katz, R. L.: Potentiation of neuromuscular blockade by verapamil. Anesthesiology60, 298–303 (1984).

    PubMed  Google Scholar 

  • Ferry, D. R., Goll, A., Glossmann, H.: Differential labelling of putative skeletal muscle calcium channels by (3H)-Nifedipine, (3H)-Nitrendipine, (3H)-Nimodipine, and (3H)-PN-200110. Nauyn-Schmiedeberg's Arch. Pharmacol.323, 276–277 (1983).

    Google Scholar 

  • Gonzales-Serratos, H., Valle-Aguilera, R., Lathrop, D. A., Garcia, Maria del Carmen. Nature289, 292–294 (1982).

    Google Scholar 

  • Gould, R. J., Murphy, K. M., Snyder, S. H.: (3H)-Nitrendipine-labelled calcium channels discriminate inorganic calcium agonists and antagonists. Proc. Natl. Acad. Sci. U.S.A.79, 3656–3660 (1982).

    PubMed  Google Scholar 

  • Hoefling, B., Renner, H., Westphal, W.: Changes of neuromuscular transmission in mammalian skeletal muscle induced by Iproveratril (Verapamil). Pfluegers Arch.375, R29–113 (1976).

    Google Scholar 

  • Ilias, W., Lackner, F., Zekert, F.: Nifedipin and Vecuronium-bromid: wie reagiert der mit Ca-Antagonisten behandelte Patient auf nichtdepolarisierende Muskelrelaxantien. Der Anästhesist34, in press (1985).

  • Ilias, W., Steinbereithner, K.: Zur Wechselwirkung der Ca-Antagonisten Nifedipin und Nisoldipin mit dem nichtdepolarisierenden Muskelrelaxans Vecuronium-Bromid im “in vivo” Rattenpräparat. Der Anästhesist34, in press (1985).

  • Israel, J. M., Meunier, J. M.: A calcium dependent acetylcholine depolarization blocked by Methoxyverapamil (D600) and procaine in snail neurones. Br. J. Pharmacol.68, 235–240 (1980).

    PubMed  Google Scholar 

  • Jenkins, L. C., Scoates, P. J.: Anesthetic implications of calcium channel blockers. Can. Anaest. Soc.32, 436–447 (1985).

    Google Scholar 

  • Kraynack, B. J., Lawson, N. W., Gintautas, J., Hon Tjoenj Tjay. Anesth. Analg.62, 827–830 (1983).

    PubMed  Google Scholar 

  • Llinás, R., Steinberg, I. Z., Walton, K.: Presynaptic calcium currents in squid giant synapse. Biophys. J.33, 289–321 (1981).

    PubMed  Google Scholar 

  • Peracchia, C., Bernardini, G.: Gap junction structure and cell-to-cell coupling regulation: is there a calmodulin involvement? Federation Proc.43, 2681–2691 (1984).

    Google Scholar 

  • Loewe, S., Muischnek, H.: Über Kombinationswirkungen. Arch. Exp. Pathol. Pharmacol.114, 313–326 (1926).

    Google Scholar 

  • Miledi, R., Parker, I.: Blocking of acetylcholine induced channels by extra cellular or intracellular application of D600. Proc. R. Soc. (Lond.)B 211, 143–150 (1980).

    Google Scholar 

  • Publicover, St. J., Duncan, Ch. J.: The action of Verapamil on the rate of spontaneous release of transmitter at the frog neuromuscular junction. Eur. J. Pharmacol.54, 119–127 (1979).

    PubMed  Google Scholar 

  • Rang, H. P.: Drugs and ionic channels: mechanism and implications, postgrad. Med. J. 57 (Suppl.), 89–97 (1981).

    Google Scholar 

  • Reves, J. C., Kissin, I., Lell, W. A., Tosone, St.: Calcium entry blockers: uses and implications for anesthesiologists. Anesthesiology57, 504–518 (1982).

    PubMed  Google Scholar 

  • Sato, T., Ono, H.: Facilitation of neuromuscular transmission by calcium antagonists Diltiazem, Nifedipine and Verapamil in the dog. Arch. Int. Pharmacodyn. Ther.249, 233–246 (1981).

    Google Scholar 

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Author notes

  1. W. Ilias

    Present address: L. Boltzmann-Institut für Experimentelle Anaesthesiologie und Intensivmedizinische Forschung, Klinik für Anaesthesie und Allgemeine Intensivmedizin der Universität Wien, Österreich

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  1. L. Boltzmann-Institut für Experimentelle Anaesthesiologie und Intensivmedizinische Forschung, Klinik für Anaesthesie und Allgemeine Intensivmedizin der Universität Wien, Österreich

    K. Steinbereithner

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  1. W. Ilias
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Ilias, W., Steinbereithner, K. Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockersin vitro . J. Neural Transmission 64, 285–293 (1985). https://doi.org/10.1007/BF01256473

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  • DOI: https://doi.org/10.1007/BF01256473

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