Abstract—The effects of ATP and adenosine on the parameters of the end plate currents of the frog’s Rana ridibunda neuromuscular synapse in the presence of cesium ions that modulate synaptic transmission were studied to identify the involvement of K+ channels in the mechanism of inhibitory presynaptic action of purine derivatives in the neuromuscular synapse of cold-blooded animals. There was a difference between the effects caused by a half-hour and one-hour action of cesium ions on the amplitude of the terminal plate currents; similar difference we noted previously in the effects of barium ions, which are blockers of some subtypes of potassium channels. In the case of exposure to cesium for 1 h, the inhibitory effect of adenosine on the amplitude of the terminal plate currents remained stable; while the inhibitory effect of ATP on the amplitude of postsynaptic responses decreased by approximately 2.5 times. The data obtained may indicate that the presynaptic inhibitory effect of ATP on the secretion of the transmitter from nerve endings can be realized through Cs+-sensitive potassium channels of the nerve terminals.
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REFERENCES
S. N. Grishin and A. U. Ziganshin, Biochemistry (Moscow) Suppl. Ser. A: Membr. Cell Biol. 9 (1), 13 (2015).
R. A. Cunha and J. A. Ribeiro, Life Sci. 68 (2), 119 (2000).
K. J. Todd and R. Robitaille, Pflugers Arch. 452 (5), 608 (2006).
G. Burnstock, T. R. Arnett, and I. R. Orriss, Purinergic Signal. 9 (4), 541 (2013).
A. U. Ziganshin, C. H. V. Hoyle, A. E. Khairullin, and S. N. Grishin, Int. J. Mol. Sci. 21 (17), 6423 (2020).
S. N. Grishin and A. U. Ziganshin, Biol. Membrany 30 (4), 243 (2013).
N. A. Castle, D. G. Haylett, and D.H. Jenkinson, Trends Neurosci. 12 (2), 59 (1989).
A. Meir, S. Ginsburg, A. Butkevitch, et al., Physiol. Rev. 79 (3), 1019 (1999).
P. A. Fuchs, J. G. Nicholls, A. R. Martin, and B. G. Wallace, From Neuron to Brain, 4 th ed. (Sinauer Assoc., 2001).
S. Grishin, A. Shakirzyanova, A. Giniatullin, et al., Eur. J. Neurosci. 21, 1271 (2005).
G. Russo, S. Masetto, and I. Prigioni, Neuroreport 6 (3), 425 (1995).
S. Zhang, Am. J. Physiol. Heart Circ. Physiol. 290 (3), 1038 (2006).
E. V. Ponomareva, E. V. Kachaeva, E. G. Altaeva, et al., Biophysics 53 (6), 615 (2008).
S. N. Grishin, Biochemistry (Moscow) Suppl. Ser. A: Membrane and Cell Biology 10 (2), 99 (2016).
B. Katz and R. Miledi, Proc. Roy. Soc. Lond. B: Biol Sci. 205 (1160), 369 (1979).
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Translated by E. Puchkov
Abbreviation: EPC, end plate currents.
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Khairullin, A.E., Valiullin, V.V., Teplov, A.Y. et al. The Effect of Cesium Ions on the Inhibitory Action of Purines in the Neuromuscular Synapse. BIOPHYSICS 66, 965–967 (2021). https://doi.org/10.1134/S0006350921060051
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DOI: https://doi.org/10.1134/S0006350921060051