Abstract
Rats were treated with MnSO4, H2O (1 mg/100 g/day, SC) for a period of 5 weeks. Thyroxine (T4) and triiodothyronine (T3) levels were measured in thyroid by radioimmunoassay. T4, T3 and thyroid-stimulating hormone (TSH) levels were also estimated by radioimmunoassay in serum. Manganese treatment produced no change in thyroid T4 and T3 levels but induced a significant decrease in serum T4, T3 and TSH levels. This decrease can be interpreted as the result of a pituitary alteration which appears to be related to the high accumulation of manganese in the pituitary gland.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amir SM, Carraway TF, Kohn LD (1973) The binding of thyrotropin to isolated bovine thyroid plasma membrane. J Biol Chem 218: 4092–4100
Bonilla E (1978) Flameless atomic absorption spectrophotometric determination of manganese in rat brain and other tissues. Clin Chem 24: 471–474
Buthieau AM, Autissier N (1977) Action des ions Mn2+ sur le metabolisme iodé thyroidien de rat. C R Soc Biol 171: 1024–1028
Deysach LJ, Ray TW (1949) Absorption of manganese by the thyroid gland of the guinea pig. Proc Soc Exp Biol Med 71: 188–189
Donaldson J, St Pierre T, Minnichi JL, Barbeau A (1973) Determination of Na+, K+, Mg2+, Cu2+, Zn2+ and Mn2+ in rat brain regions. Can J Biochem 51: 87–92
Heninger RW, Albright EC (1966) Effect of iodine deficiency on iodine containing compounds of rat tissues. Endocrinology 79: 309–315
Kaellis E (1970) Effect of manganous ions on thyroidal iodine metabolism in the rat. Proc Soc Exp Biol Med 135: 216–218
Michel R, Rosner B, Autissier N (1969) Synthèses et activités biologiques de certains dérivés thyroxiniens et adrénergiques. XII — Rétention prolongée du manganèse dans la thyroide et l'hypophyse du rat. Bull Soc Chim Biol 51: 737–741
Ray TW, Deysach LJ (1942) Storage of Mn by thyroid: effect on 0 consumption of guinea pig. Proc Soc Exp Biol Med 51: 228–231
Shukla GS, Dubey MP, Chandra SV (1980) Manganese induced biochemical changes in growing versus adult rats. Arch Environ Contam Toxicol 9: 383–391
Tate RL, Schwartz HI, Holmes JM, Kohn LD (1975) Thyrotropin receptors in thyroid plasma membranes. Characteristics of thyrotropin binding and solubilization of thyrotropin receptor activity by tryptic digestion. J Biol Chem 250: 6509–6515
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Buthieau, A.M., Autissier, N. Effects of manganese ions on thyroid function in rat. Arch Toxicol 54, 243–246 (1983). https://doi.org/10.1007/BF01239208
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01239208