Summary
Conscious male rhesus monkeys were given epinephrine bitartrate (1 μg/kg.min) through a catheter implanted in the right internal jugular vein. Blood samples were taken from the portal vein through another catheter before, during, and after a 15-minute-long jugular infusion. Sugar in the plasma rose during, and was still high 10 min after the infusion, while mean immunoreactive insulin decreased during the infusion and rose dramatically after its termination. Ergotamine tartrate (14 μg/kg.min) while not preventing a rise in plasma sugar concentration, inhibited the expected insulin decrease during epinephrine infusion.
Résumé
Du bitartrate d'adrénaline (1 μg/kg.min) a été administré à des singes rhésus mâles éveillés, par un cathéter implanté dans la veine jugulaire interne droite. Des échantillons de sang étaient prélevés de la veine porte par un autre cathéter, avant, pendant et après une infusion jugulaire de 15 min. Le sucre du plasma augmentait pendant l'infusion et était encore élevé 10 min après celle-ci, alors que la concentration moyenne d'insuline immunoréactive diminuait pendant l'infusion et augmentait fortement quand elle était terminée. Alors que le tartrate d'ergotamine (14 μg/kg.min) n'empêchait pas l'augmentation de la concentration du sucre du plasma, il inhibait la diminution attendue de l'insuline, pendant l'infusion d'adrénaline.
Zusammenfassung
Männliche Rhesus-Affen erhielten 1 μg/kg.min Adrenalintartrat durch einen Katheter in die rechte vena jugularis interna. Aus einem Portalvenenkatheter wurden vor, während und nach der 15-minütigen Infusion in die Jugularvene Blutproben entnommen. Die Blutzuckerspiegel stiegen unter der Infusion an und waren 10 min danach noch erhöht, während das immunoreaktive Insulin unter der Infusion abfiel, um erst nach ihrer Beendigung stark anzusteigen. 14 μg/kg.min Ergotamintartrat verhinderten zwar den Blutzuckeranstieg nicht, führten aber zu einer Hemmung des Insulinabfalls während der Adrenalin-Infusion.
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This research was supported in part by Grants: NASA NS-G-(T)-89, USPHS 6678-2, USPHS AM 09748-02
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Miller, R.E., Soeldner, J.S. Suppression of portal venous insulin concentration by epinephrine in the conscious monkey. Diabetologia 5, 179–182 (1969). https://doi.org/10.1007/BF01213676
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DOI: https://doi.org/10.1007/BF01213676