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Effect of pH, agitation and aeration on hyaluronic acid production byStreptococcus zooepidemicus

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Summary

The optimum pH for both the rate of production and yield of hyaluronic acid (HA) byStreptococcus zooepidemicus from glucose medium was 6.7±0.2 under anaerobic conditions. High agitation rates (600 rpm) gave superior results compared to 300 rpm. Aeration of the culture (0.3 VVM) improved the HA yield, but not the rate of production and lead to some acetate and CO2 being formed, in addition to lactate and HA.

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Authors and Affiliations

  1. Department of Chemical Engineering, The University of Queensland, 4072, Queensland, Australia

    Michael R. Johns, Lin-Tang Goh & Andreas Oeggerli

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  1. Michael R. Johns
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  2. Lin-Tang Goh
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  3. Andreas Oeggerli
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Johns, M.R., Goh, LT. & Oeggerli, A. Effect of pH, agitation and aeration on hyaluronic acid production byStreptococcus zooepidemicus . Biotechnol Lett 16, 507–512 (1994). https://doi.org/10.1007/BF01023334

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  • DOI: https://doi.org/10.1007/BF01023334

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