Abstract
The effects of an infection with 200Trichinella spiralis larvae on the intestinal phospholipase B activity and bone marrow eosinophilia of congenitally athymic (nude) mice (BALB/c; NU/NU) were studied. Nude mice were used since it had been shown that they do not undergo a typical worm expulsion and also they lack a thymus. The results showed that nude mice do not develop either an increased bone marrow eosinophilia or an elevation in intestinal phospholipase B activity. The findings thus support the hypothesis that phospholipase B is involved in the expulsion of parasitic worms and that elevated enzyme levels and expulsion are thymus cell dependent.
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Goven, A.J., Moore, G.W. Phospholipase B activity in congenitally athymic (nude) mice infected withTrichinella spiralis . Z. Parasitenkd. 61, 265–269 (1980). https://doi.org/10.1007/BF00925517
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DOI: https://doi.org/10.1007/BF00925517