Summary
In a case of Lewy body disease incidentally found at autopsy, numerous dense core vesicles, 80–200 nm in diameter, were seen in the neuronal perikarya of the locus caeruleus. They were particularly numerous in the vicinity of the Lewy bodies. The change seems to occur at the early stage of Lewy body production and may represent an additional morphologic clue to abnormal catecholamine metabolism in Parkinson's disease.
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Supported by the Medical Research Service of the Veterans Administration
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Watanabe, I., Vachal, E. & Tomita, T. Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study. Acta Neuropathol 39, 173–175 (1977). https://doi.org/10.1007/BF00703325
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DOI: https://doi.org/10.1007/BF00703325