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Papovavirus-related RNA sequences in human neurogenic tumours

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Summary

Thirty-two human brain tumours were investigated for the presence of papovavirus-related RNA sequences. Radiolabelled viral DNAs isolated from SV40, BKV, HDV, and BPV were hybridized insitu on to tumour kryostat sections under conditions that detect complementary RNA. SV40-related RNA was detectable in 34% of all tumours tested but was not found in normal human brain tissue. SV 40-positive tumours included 1/1 angiofibroma, 1/4 astrocytomas, 2/4 metastatic brain tumours, 1/1 melanoma, 3/7 meningiomas, 2/4 neurinomas, 1/2 oligodendrogliomas. Bovine papilloma virus-, BKV-, and HDV-related RNAs were absent from all tissues tested. The presence of SV 40-related nucleic acids in a large number of human neurogenic tumours may reflect a viral involvement in the etiology of these tumours.

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  1. H. Ibelgaufts

    Present address: Institut für Biochemie, Universität München, Karlstr. 23, D-8000, München 2, Federal Republic of Germany

Authors and Affiliations

  1. Institute of Animal Genetics, University of Edinburgh, West Mains Road, Edinburgh, Scotland

    H. Ibelgaufts & K. W. Jones

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  1. H. Ibelgaufts
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Ibelgaufts, H., Jones, K.W. Papovavirus-related RNA sequences in human neurogenic tumours. Acta Neuropathol 56, 118–122 (1982). https://doi.org/10.1007/BF00690582

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