Summary
The α-adrenoceptor ligand, 3H-WB 4101 binds to a single population of independent sites in the rat heart ventricle. These sites are not affected by chemical sympathectomy with 6-hydroxydopamine and thus appear to be located postsynaptically. The relative order of potencies for displacement of 3H-WB 4101 binding: prazosin>phentolamine>yohimbine, is characteristic of that of the α1 type of adrenoceptors. In heart ventricle 3H WB-4101 thus seems to label specifically postsynaptically located α1-adrenoceptors. The significance of the specificity of this ligand is discussed with relevance to its use in the central nervous system.
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Raisman, R., Briley, M. & Langer, S.Z. Specific labelling of postsynaptic α1 adrenoceptors in rat heart ventricle by 3H-WB 4101. Naunyn-Schmiedeberg's Arch. Pharmacol. 307, 223–226 (1979). https://doi.org/10.1007/BF00505937
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DOI: https://doi.org/10.1007/BF00505937