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Stimulation of calcium uptake into aortic microsomes by cyclic AMP and cyclic AMP-dependent protein kinase

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Summary

Enhancement of calcium uptake into rabbit aortic microsomes was seen at a cyclic AMP concentration of 10−6M in the presence of cyclic AMP-dependent protein kinase (ATP: protein phosphotransferase, EC 2.7.1.37). Protein kinase alone also increased calcium uptake, but cyclic AMP alone was without effect. The results suggest that stimulation of calcium sequestration may be the mechanism of cyclic AMP involvement in vascular smooth muscle relaxation.

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Authors and Affiliations

  1. Department of Pharmacology, College of Medicine, University of South Florida Medical Center, 33612, Tampa, Florida, USA

    David F. Fitzpatrick & Andor Szentivanyi

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  1. David F. Fitzpatrick
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  2. Andor Szentivanyi
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Fitzpatrick, D.F., Szentivanyi, A. Stimulation of calcium uptake into aortic microsomes by cyclic AMP and cyclic AMP-dependent protein kinase. Naunyn-Schmiedeberg's Arch. Pharmacol. 298, 255–257 (1977). https://doi.org/10.1007/BF00500896

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  • DOI: https://doi.org/10.1007/BF00500896

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