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The activity and distribution of gamma-glutamyl transpeptidase (y-GT) in human lung cancers serially transplanted in nude mice

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Summary

Gamma-glutamyl transpeptidase (y-GT) activity and distribution were investigated in different types of human lung cancers (three epidermoid carcinomas, one large cell carcinoma) which were maintained by serial transplantation in nude mice. All transplanted tumour fragments were positive for the enzyme. In the epidermoid carcinomas, y-GT levels were related to the degree of tumour differentiation. Enzyme activity in tumour fragments was always higher than that found in normal adult human lung tissue, and was, in general, maintained throughout the transplantation series.

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Authors and Affiliations

  1. Division of Cell Biology, Institute of Anatomy, University of Zurich, Gloriastrasse 19, CH-8006, Zurich, Switzerland

    Peter Groscurth, Norman Fleming & Gonzague S. Kistler

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  1. Peter Groscurth
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  2. Norman Fleming
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  3. Gonzague S. Kistler
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Additional information

This work was supported by a grant from A.S.F.C., Switzerland, and the Jubiläumsspende 1970 der Zürcher Kantonalbank

N.F. was supported during part of the work by a Royal Society European Science Exchange Programme Fellowship

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Groscurth, P., Fleming, N. & Kistler, G.S. The activity and distribution of gamma-glutamyl transpeptidase (y-GT) in human lung cancers serially transplanted in nude mice. Histochemistry 53, 135–142 (1977). https://doi.org/10.1007/BF00498488

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  • DOI: https://doi.org/10.1007/BF00498488

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