Abstract
A deoxyribonuclease, called DNase-1, that is active at acid pH in the presence of EDTA has been studied in Drosophila melanogaster. The locus for the enzyme maps genetically to 61.8 on the right arm of the third chromosome. Cytogenetically, DNase-1 has been localized to within five to ten bands between 90C-2 and 90E. This analysis utilizes both electrophoretic variants and the Y-autosome translocations of Lindsley et al. (1972). DNase-1 is present in all stages of the life cycle, and the paternal genome actively contributes DNase-1 to the embryo between 0 and 1 hr after fertilization.
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This investigation was supported by Research Grant GM-01035 from the National Institutes of Health.
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Detwiler, C., MacIntyre, R. A genetic and developmental analysis of an acid deoxyribonuclease in Drosophila melanogaster . Biochem Genet 16, 1113–1134 (1978). https://doi.org/10.1007/BF00484532
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DOI: https://doi.org/10.1007/BF00484532