Abstract
Acute administration of 4 mg/kg d-amphetamine in the marmoset results in a large increase in small head movements (checking), an almost total suppression of purposeful activities and social interaction, but little change in the amount of locomotion. Checking behaviour is blocked in a dose dependent manner by 0.03–0.18 mg/kg haloperidol but not by propranolol, aceperone or diazepam, suggesting dopaminergic mediation of this behaviour. The loss of activities and social interaction after amphetamine is not antagonized by any of the drugs used in this study. Locomotion is decreased by haloperidol, propranolol and diazepam in amphetamine treated animals and by haloperidol and aceperone in normal animals.
Similar content being viewed by others
References
Angrist, B., Rotrosen, J., Kleinberg, D., Merrian, V., Gershon, S.: Dopaminergic agonist properties of ephedrines — theoretical implications. Psychopharmacology 55, 115–120 (1977)
Atsmon, A., Blum, I., Steiner, M., Latz, A., Wijsenbeck, H.: Further studies with propranolol in psychotic patients. Psychopharmacologia 27, 249–254 (1972)
Carlsson, A., Fuxe, K., Hamberger, B., Lindqvist, M.: Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons. Acta Physiol. Scand. 67, 481–497 (1966)
Costa, E., Greengard, P.: Mechanisms of action of benzodiazepines. Adv. Biochem. Psychopharmacol. Vol. 14. New York: Raven Press 1975
Crow, T. J., Johnstone, E. C.: Stereochemical specificity in the antipsychotic effects of flupenthixol in man. Brit. J. Pharmacol. 59, 466P (1977)
Del Rio, J., Fuentes, J. A.: Further studies on the antagonism of stereotyped behaviour induced by amphetamine. Eur. J. Pharmacol. 8, 73–78 (1969)
Estler, C.-J., Ammon, H. P. T.: Modification by two beta-adrenergic blocking drugs of the effects of methamphetamine on behaviour and brain metabolism of mice. J. Neurochem. 18, 777–779 (1971)
Ridley, R. M.: The effects of d-amphetamine and apomorphine on visually determined behaviour in the marmoset. Paper read at British Pharmacological Society, March 1978
Ridley, R. M., Baker, H. F., Crow, T. J.: Behavioural effects of amphetamine and related stimulants; the importance of species differences as demonstrated by a study in the marmoset. In: Amphetamines and related stimulants: chemical, biological, clinical, and sociological aspects, J. Caldwell, ed. Ohio: CRC Press 1978
Rolinski, Z., Scheel-Kruger, J.: The effect of dopamine and noradrenaline antagonists on amphetamine induced locomotor activity in mice and rats. Acta Pharmacol. Toxicol. 33, 385–399 (1973)
Scheel-Kruger, J.: Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Eur. J. Pharmacol. 14, 47–59 (1971)
Scraggs, P. R., Ridley, R. M.: Behavioural effects of amphetamine in a small primate: relative potencies of the d- and l-isomers. Psychopharmacology 59, 243–245 (1978)
Weinstock, M., Speiser, Z.: Modification by propranolol and related compounds of motor activity and stereotyped behaviour induced in the rat by amphetamine. Eur. J. Pharmacol. 25, 29–35 (1974)
Yorkston, N. J., Zaki, S. A., Malik, M. K. U., Morrison, R. C., Havard, C. W. H.: Propranolol in the control of schizophrenic symptoms. Brit. Med. J. 4, 633–635 (1974)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Scraggs, P.R., Ridley, R.M. The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset. Psychopharmacology 62, 41–45 (1979). https://doi.org/10.1007/BF00426033
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00426033