Abstract
The methylphenidate antagonistic effect of haloperidol was investigated in normal and haloperidol tolerant mice under the influence of cholinergic and anticholinergic treatment. Physostigmine increased the potency of haloperidol against stereotypies induced by methylphenidate, whereas scopolamine reduced the effect of haloperidol. The effect of haloperidol was influenced both in non-pretreated mice and in haloperidol-pretreated mice. It is concluded, that a cholinergic-dopaminergic balance is of importance for the antagonistic effect of a neuropeptic agent against methylphenidate-induced gnawing-compulsion in normal mice as well as in mice which have become tolerant to neuroleptics.
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Fjalland, B., Nielsen, I.M. Methylphenidate antagonism of haloperidol, interaction with cholinergic and anticholinergic drugs. Psychopharmacologia 34, 111–118 (1974). https://doi.org/10.1007/BF00421935
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DOI: https://doi.org/10.1007/BF00421935