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Reduced [3H]-tetrodotoxin binding in the nap ts paralytic mutant of Drosophila

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Summary

The temperature-sensitive paralytic mutant of Drosophila, nap ts, has been shown to have defects in axonal physiology which suggest that it codes for a component of the voltage-sensitive sodium channel. Ligand binding studies using tritiated tetrodotoxin, a sodium channel antagonist, show a decrease in the apparent number of sodium channels in nap ts, providing additional support for this hypothesis.

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Author notes

  1. Lawrence M. Kauvar

    Present address: Department of Biochemistry and Biophysics, University of California, 94143, San Francisco, California, USA

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  1. Division of Biology 156-29, California Institute of Technology, 91125, Pasadena, CA, USA

    Lawrence M. Kauvar

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  1. Lawrence M. Kauvar
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Communicated by O. Siddiqi

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Kauvar, L.M. Reduced [3H]-tetrodotoxin binding in the nap ts paralytic mutant of Drosophila . Molec. Gen. Genet. 187, 172–173 (1982). https://doi.org/10.1007/BF00384402

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  • DOI: https://doi.org/10.1007/BF00384402

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