Abstract
Quinacrine (Q-band) and centromeric heterochromatin (C-band) patterns of metaphase chromosomes of two subspecies of Mus musculus were compared. M. m. musculus (the laboratory mouse) and M. m. molossinus (a subspecies from Southeast Asia) had similar Q-band patterns along the length of the chromosomes, but differences were observed in the centromeric region of some chromosomes. The two subspecies had very different distributions of C-band material. Antibodies to 5-methylcytosine were bound to regions of the chromosome corresponding to the C-bands in each animal. These findings support the idea that satellite DNA, which is concentrated in the C-band region, changes more quickly than bulk DNA. The interfertility of these two subspecies permits the development of a musculus strain carrying normal marker chromosomes for genetic studies.
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Dev, V.G., Miller, D.A., Tantravahi, R. et al. Chromosome markers in Mus musculus: Differences in C-banding between the subspecies M. m. musculus and M. m. molossinus . Chromosoma 53, 335–344 (1975). https://doi.org/10.1007/BF00294081
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DOI: https://doi.org/10.1007/BF00294081