Summary
The frequencies of base-line and Mitomycin-C (MMC) induced sister chromatid exchanges (SCE) were surveyed in four inbred strains of mice. In contrast to the C57B1/6J, CBA/J, and A/J strains where frequencies of SCE increased linearly with increasing dose of MMC, levels of SCE were significantly lower in AKR/J mice at high MMC concentrations. At a dose of 5 mg/kg MMC, chromosomal aberrations were more frequent in bone marrow cells of AKR/J mice than in C57B1/6J mice. These observations suggest an altered response to DNA damage in the AKR mouse strain.
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Kram, D., Schneider, E.L. Reduced frequencies of Mitomycin-C induced sister chromatid exchanges in AKR Mice. Hum Genet 41, 45–51 (1978). https://doi.org/10.1007/BF00278870
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DOI: https://doi.org/10.1007/BF00278870