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The cell cycle, cancer development and therapy

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Abstract

The process of cell division plays a vital role in cancer progression. Cell proliferation and error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes during cell division generate changes in chromosome content and alter the balances of chromosomes number. Any defects in expression of TIF1 family proteins, SAC proteins network, mitotic checkpoint proteins involved in chromosome mis-segregation and cancer development. Here we discuss the function of organelles deal with the chromosome segregation machinery, proteins and correction mechanisms involved in the accurate chromosome segregation during mitosis.

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Authors and Affiliations

  1. Research Center of Oils and Fats (RCOF), Kermanshah University of Medical Sciences, Kermanshah, Iran

    Elaheh Jamasbi, Mona Hamelian & Kambiz Varmira

  2. The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia

    Mohammed Akhter Hossain

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  1. Elaheh Jamasbi
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Jamasbi, E., Hamelian, M., Hossain, M.A. et al. The cell cycle, cancer development and therapy. Mol Biol Rep 49, 10875–10883 (2022). https://doi.org/10.1007/s11033-022-07788-1

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