Summary
Bf allele frequencies in a material of 172 unrelated Norwegians are given. Bf/HLA linkage relations in 49 informative matings with 178 children, and Bf/HLA association data of a material of 212 Bf-HLA haplotypes are presented. Of 171 informative meioses, there were no Bf-HLA-B recombinations, while 3 out of 158 Bf-HLA-A informative meioses showed recombination. There is significant association between the Bf F and the HLA-BW 35 allele.
It is concluded that the Bf locus is situated on the HLA-B side of HLA-A within the HLA region, in very close proximity to HLA-B.
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Olaisen, B., Teisberg, P., Gedde-Dahl, T. et al. The Bf locus in the HLA region of chromosome 6: Linkage and association studies. Hum Genet 30, 291–296 (1975). https://doi.org/10.1007/BF00275141
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DOI: https://doi.org/10.1007/BF00275141