Summary
A fatal case of lactic acidosis in a 84 year old diabetic woman taking buformin is reported. Buformin concentrations in serum, other body fluids and tissues were measured by gas chromatography. Serum buformin concentration at admission was 5.5 mg/1. Postmortem concentrations were: in serum 3.2mg/l; in lung 2.8mg/kg wet weight; in heart 3.0mg/kg; in pericardial fluid 3.5 mg/1; in liver 5.2 mg/kg; in bile 6.3 mg/1; and in kidney 98 mg/kg.
Article PDF
Similar content being viewed by others
References
Lintz W, Berger W, Aenishaenslin W, Kutova V, Baerlocher Ch, Kapp JP, Beckmann R (1974) Butylbiguanide concentration in plasma, liver, and intestine after intravenous and oral administration to man. Eur J Clin Pharmacol 7: 433–448
Berger W, Mehnert-Aner S, Mülly K, Heierli Ch, Ritz R (1976) 10 Fälle von Lactatazidose unter Biguanidtherapie (Buformin und Phenformin). Schweiz Med Wochenschr 106: 1830–1834
Althoff PH, Fassbinder W, Neubauer M, Koch KM, Schöffling K (1978) Hämodialyse bei der Behandlung der biguanidinduzierten Lactacidose. Dtsch Med Wochenschr 103: 61–68
Irsigler K, Kritz H, Regal H, Foltin E (1978) Risiko zur Laktazidose? Wien Klin Wochenschr 90: 332–337
Grpot G de, Maes RAA, Sangster B, Heijst ANP van, Verdonck LF (1980) A specific method for the analysis of buformin in pre- and postmortem human material. Proceedings of the European Meeting of the International Association of Forensic Toxicologists, Glasgow, August 1979. Croom Helm, London, p 165–172
Alberti KGMM, Nattrass M (1977) Lactic acidosis: Lancet II: 25–29
Ng ML, Levy MN, Zieske HA (1967) Effects of changes of pH and carbon dioxide tension on left ventricular performance. Am J Physiol 213: 115–120
Wildenthal K, Mierzwiak DS, Myers RW, Mitchell JH (1968) Effects of acute lactic acidosis on left ventricular performance. Am J Physiol 214: 1352–1359
Zähringer J, Cyran J, Lüderitz B (1978) Laktazidose bei Biguanidtherapie: Diagnostik und Therapie. Schweiz Med Wochenschr 108: 1838–1846
Bottermann P, Schweigart U, Ermler R (1976) Untersuchungen zum Wirkungsmechanismus von Buformin mit Hilfe tritiierter Glucose bei stoffwechselgesunden Personen. Med Klin 71: 1423–1428
Deppermann D, Heidland A, Ritz E, Hört W (1978) Lactat- Azidose. Eine mögliche Komplikation der Buformin-Therapie. Klin Wochenschr 56: 843–853
Luft D, Schmülling RM, Eggstein M (1978) Lactic acidosis in biguanide-treated diabetics. Diabetologia 14: 75–87
Beckmann R, Lintz W, Schmidt-Böthelt E (1971) Evaluation of a sustained release from of the oral antidiabetic butylbi- guanide (Silubin®-Retard). Eur J Clin Pharmacol 3: 221–228
Losert W, Kolb K-H, Bitterling G (1972) Verteilung von 1- Butyl-biguanid-14C im Organismus von Ratten und Meer- schweinen. Arzneim Forsch 22: 937–946
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Verdonck, L.F., Sangster, B., van Heijst, A.N.P. et al. Buformin concentrations in a case of fatal lactic acidosis. Diabetologia 20, 45–46 (1981). https://doi.org/10.1007/BF00253815
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00253815