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CNS depressant activity of Castanopsis indica leaves

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Abstract

Castanopsis indica (Roxb. ex Lindl.) A.DC. (Fagaceae) is commonly known as ‘Dhalne katus’ and ‘Indian chestnut tree’, found throughout the Himalayan region. The purpose of this investigation was to evaluate the effect of methanol extract of C. indica leaves (MECI) on Central Nervous System using a number of neuropharmacological experimental models in Swiss albino mice. The treatment with MECI at doses of 25 and 50 mg/kg, i.p. caused: signs of central nervous system depressant action confirmed by significant inhibitory effect on acetic acid induced writhing as compared with acetic acid control group indicate an analgesic effect. Anticonvulsant activity was seen as there was delays in the onset of pentylenetetrazole (PTZ) induce convulsion as well as decrease in its mortality rate. The MECI produced a dose-dependent reduction of the onset and potentiated duration of pentobarbitone-induced hypnosis, reduction of locomotor and muscle relaxant activities determining by using actophotometer and rotarod tests. MECI in a dose-dependent manner significantly reduced the immobility time of mice in both forced swim test (FST) and tail suspension test (TST). These results suggest that the MECI has an analgesic effect, behave as a potential anticonvulsant and central nervous system depressant action.

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Acknowledgements

The financial assistance of Ministry of Human Resource Development (MHRD), Ministry of Chemicals and Fertilizers, Government of India, NIPER Kolkata, Jadavpur University, Department of Pharmaceutical Technology, Kolkata and AICTE (RPS-File No: 8023/BOR/RID/RPS(NER)-91/2010-11), New Delhi, India are gratefully acknowledged for providing technical support.

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Authors and Affiliations

  1. National Institute of Pharmaceutical Education and Research, Kolkata, 700032, WB, India

    Narayan Dolai

  2. Himalayan Pharmacy Institute, Majhitar, East Sikkim, 737136, Sikkim, India

    I. Karmakar & Pallab Kanti Haldar

  3. Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, WB, India

    R. B. S. Kumar & Pallab Kanti Haldar

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  1. Narayan Dolai
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  2. I. Karmakar
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  3. R. B. S. Kumar
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  4. Pallab Kanti Haldar
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Correspondence to Narayan Dolai or Pallab Kanti Haldar.

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Dolai, N., Karmakar, I., Kumar, R.B.S. et al. CNS depressant activity of Castanopsis indica leaves. Orient Pharm Exp Med 12, 135–140 (2012). https://doi.org/10.1007/s13596-012-0058-2

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  • DOI: https://doi.org/10.1007/s13596-012-0058-2

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