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Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models

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Abstract

This study was performed out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animals. The antinociceptive activity was measured using the abdominal constriction, hot plate, and formalin tests. The anti-inflammatory and antipyretic activities were measured using the carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, obtained after 72 h soaking of the air-dried leaves in distilled water and then prepared in the doses of 13.2, 66.0, 132.0, and 660.0 mg/kg, was administered subcutaneously 30 min before subjecting the animals to the assays mentioned above. Generally, the extract, at all doses used, was found to have significant (P < 0.05) concentration-independent antinociceptive, anti-inflammatory, and anti-pyretic activity. In conclusion, the aqueous extract of D. linearis has antinociceptive, anti-inflammatory, and antipyretic activity, supporting previous claims of its traditional use by the Malays to treat various ailments, particularly fever.

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Acknowledgments

This study was supported by a research grant from Universiti Industri Selangor, Malaysia (project code number 03013; project vote number 3090103013). The authors would like to thank Universiti Putra Malaysia for the facilities and Mrs Fatimah Corazon Abdullah for her help in the preparation of the manuscript.

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Authors and Affiliations

  1. Faculty of Pharmacy, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia

    Zainul Amiruddin Zakaria

  2. Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A7/A, Seksyen 7, 40000, Shah Alam, Selangor, Malaysia

    Zainul Amiruddin Zakaria, Zuleen Delina Fasya Abdul Ghani, Raden Nur Suraya Raden Mohd. Nor & Hanan Kumar Gopalan

  3. Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia

    Mohd. Roslan Sulaiman, Abdul Manan Mat Jais & Muhammad Nazrul Somchit

  4. Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia

    Arifah Abdul Kader & Johari Ripin

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  1. Zainul Amiruddin Zakaria
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  2. Zuleen Delina Fasya Abdul Ghani
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Correspondence to Zainul Amiruddin Zakaria.

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Zakaria, Z.A., Abdul Ghani, Z.D.F., Raden Mohd. Nor, R.N.S. et al. Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. J Nat Med 62, 179–187 (2008). https://doi.org/10.1007/s11418-007-0224-x

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  • DOI: https://doi.org/10.1007/s11418-007-0224-x

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