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Kinetic characterization of a novel cationic 99mTc(I)-tricarbonyl complex, 99mTc-15C5-PNP, for myocardial perfusion imaging

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Intense liver uptake of 99mTc-sestamibi (MIBI) often interferes with visualization of myocardial perfusion in the inferior wall of the left ventricle. To develop improved myocardial perfusion agents, crown ether-containing dithiocarbamates and bisphosphines have been introduced in recent years. This study was designed to investigate the myocardial imaging properties and in vivo kinetics of a cationic 99mTc(I)-tricarbonyl complex, 99mTc-15C5-PNP, in comparison with MIBI.

Methods

Dynamic cardiac images were acquired for 60 minutes after intravenous tracer injection using a small-animal SPECT system in healthy control rats and rats with myocardial infarcts. Myocardial and liver time-activity curves were generated for radiopharmaceutical kinetic analysis.

Results

Good visualization of the left ventricular wall and perfusion defects could be achieved 20 minutes after 99mTc-15C5-PNP administration. 99mTc-15C5-PNP images in all hearts with infarcts showed perfusion defects, which were comparable to MIBI images. The kinetic curves plotted from 1 to 60 minutes demonstrated that 99mTc-15C5-PNP has a shorter washout half-life (6.4 ± 3.2 vs 124 ± 30.5 minutes, P < .01) in the liver, lower residual liver activity (14.5 ± 10.2% vs 36.5 ± 28.9%, P < .01), and higher heart/liver ratio than MIBI.

Conclusions

99mTc-15C5-PNP has potential for rapid myocardial perfusion imaging with low liver uptake.

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Acknowledgements

This work was supported by NIBIB Grant P41-EB002035. The authors have indicated they have no financial conflicts of interest.

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Authors and Affiliations

  1. Department of Radiology, University of Arizona, P.O. Box 245067, Tucson, AZ, 85724-5067, USA

    Zhonglin Liu MD, Liying Chen PhD, Christy Barber, Gail D. Stevenson DVM, Lars R. Furenlid PhD, Harrison H. Barrett PhD & James M. Woolfenden MD

  2. School of Health Sciences, Purdue University, West Lafayette, IN, USA

    Shuang Liu PhD

Authors
  1. Zhonglin Liu MD
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  2. Liying Chen PhD
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  3. Shuang Liu PhD
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  4. Christy Barber
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  5. Gail D. Stevenson DVM
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  6. Lars R. Furenlid PhD
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  8. James M. Woolfenden MD
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Corresponding author

Correspondence to Zhonglin Liu MD.

Additional information

See related editorial on doi:10.1007/s12350-010-9275-6.

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Liu, Z., Chen, L., Liu, S. et al. Kinetic characterization of a novel cationic 99mTc(I)-tricarbonyl complex, 99mTc-15C5-PNP, for myocardial perfusion imaging. J. Nucl. Cardiol. 17, 858–867 (2010). https://doi.org/10.1007/s12350-010-9262-y

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  • DOI: https://doi.org/10.1007/s12350-010-9262-y

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