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Cartap and carbofuran induced alterations in serum lipid profile of Wistar rats

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Abstract

Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein, total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum lipids in rat.

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Authors and Affiliations

  1. Department of Biochemistry, University of Allahabad, Allahabad, 211002, India

    Devendra K. Rai, Aradhna Gupta & Bechan Sharma

  2. Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211002, India

    Prashant Kumar Rai & Geeta Watal

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  1. Devendra K. Rai
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  2. Prashant Kumar Rai
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  3. Aradhna Gupta
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  4. Geeta Watal
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  5. Bechan Sharma
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Correspondence to Bechan Sharma.

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Rai, D.K., Rai, P.K., Gupta, A. et al. Cartap and carbofuran induced alterations in serum lipid profile of Wistar rats. Indian J Clin Biochem 24, 198–201 (2009). https://doi.org/10.1007/s12291-009-0036-8

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  • DOI: https://doi.org/10.1007/s12291-009-0036-8

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