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Four FCRL3 Gene Polymorphisms (FCRL3_3, _5, _6, _8) Confer Susceptibility to Multiple Sclerosis: Results from a Case-Control Study

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Abstract

Multiple sclerosis (MS) is an autoimmune/inflammatory neurodegenerative disease which mainly affects the central nervous system in young adults. Fc-receptor-like-3 (FCRL3) gene, which involved in immune cell regulation, has drawn lots of attentions. This study aims to investigate the association between common polymorphisms of FCRL3 gene and MS risk in a Chinese Han population. Nine single nucleotide polymorphisms (SNPs) were genotyped in 120 patients and 240 healthy controls through PCR assay. t test and chi-square test was conducted to find a possible association between FCRL3 genetic mutations and risk of MS. This analysis results performed that four SNPs, rs7528684 (FCRL3_3), rs945635 (FCRL3_5), rs3761959 (FCRL3_6), and rs2282284 (FCRL3_8), were significantly associated with the risk of MS. Further haplotype analysis showed two haplotypes of FCRL3_3, 5, 6, 8, CCAG and CGAG, presented the significant associations with the susceptibility to MS. Four SNPs in FCRL3 gene could possibly associate with the susceptibility of MS in a Chinese Han population. Moreover, the haplotype analysis confirmed that the linkage disequilibrium exists in polymorphisms in FCRL3. Based on the supporting evidence, we deduced that FCRL3_3C, FCRL3_5C, FCRL3_6A, and FCRL3_8G caused increased risk of MS. Nevertheless, large cohort studies are required in the future to validate the autoimmune function.

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    Authors and Affiliations

    1. Department of Nuclear Medicine, Tangdu Hospital, the Fourth Military Medical University (FMMU), No. 569 Xinsi Road, Baqiao District, Xi’an, 710038, China

      Menghui Yuan, Longxiao Wei, Runsuo Zhou, Qianrong Bai, Yixin Wei, Wei Zhang & Yong Huang

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    1. Menghui Yuan
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    2. Longxiao Wei
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    Correspondence to Longxiao Wei.

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    Menghui Yuan and Longxiao Wei contributed equally to this work.

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    Yuan, M., Wei, L., Zhou, R. et al. Four FCRL3 Gene Polymorphisms (FCRL3_3, _5, _6, _8) Confer Susceptibility to Multiple Sclerosis: Results from a Case-Control Study. Mol Neurobiol 53, 2029–2035 (2016). https://doi.org/10.1007/s12035-015-9149-7

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