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Modifiers of expression in mutations of mismatch repair gene carriers in hereditary nonpolyposis colorectal cancer

  • Published:
Current Colorectal Cancer Reports

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Patients with this syndrome are at increased risk for a variety of cancers. Among individuals with MMR mutations, there is considerable variation in the age of cancer onset, probably resulting from a combination of other genetic and environmental factors. This review describes recent advances in identifying these genetic risk factors in HNPCC patients with MMR mutations. Recent research has identified potential modifiers of MMR gene expression that are involved in cell cycle control, DNA repair, and metabolism and the pathways through which these modifiers act. These findings will be important in identifying individuals that are more susceptible to developing cancer at an earlier age and may aid in the development of strategies to prevent HNPCC.

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Authors and Affiliations

  1. Department of Epidemiology, Unit 1365, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA

    Chongjuan Wei PhD

Authors
  1. Jinyun Chen MD, PharmD
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  2. Jing Zhu MD
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  3. Mala Pande MBBS, MPH
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  4. Joshua Amos BS
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  5. Marsha L. Frazier PhD
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  6. Chongjuan Wei PhD
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Correspondence to Chongjuan Wei PhD.

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Chen, J., Zhu, J., Pande, M. et al. Modifiers of expression in mutations of mismatch repair gene carriers in hereditary nonpolyposis colorectal cancer. Curr colorectal cancer rep 2, 179–184 (2006). https://doi.org/10.1007/s11888-006-0020-0

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  • DOI: https://doi.org/10.1007/s11888-006-0020-0

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