, 63:66

Collagen scaffolds for orthopedic regenerative medicine


  • Gráinne M. Cunniffe
    • Department of Mechanical and Manufacturing EngineeringRoyal College of Surgeons in Ireland
    • Department of AnatomyRoyal College of Surgeons in Ireland
    • Trinity Centre for BioengineeringTrinity College
Biomaterials for Regenerative Medicine Overview

DOI: 10.1007/s11837-011-0061-y

Cite this article as:
Cunniffe, G.M. & O’Brien, F.J. JOM (2011) 63: 66. doi:10.1007/s11837-011-0061-y


Collagen and collagen-based scaffolds offer distinct advantages when selected as biomaterials for use across a broad spectrum of regenerative medicine applications. However, relatively poor mechanical properties are often perceived to limit their usefulness for orthopedic applications. These problems can be overcome through enhanced crosslinking mechanisms or through the addition of a second, stiffer phase such as hydroxyapatite, thus allowing tailored composite scaffolds to meet specific tissue requirements. This overview will highlight the current state of the art of these scaffolds, and consider the exciting prospects and future directions of collagen-based technologies for orthopedic regenerative medicine.

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© TMS 2011