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Double inversion recovery imaging improves the evaluation of gray matter volume losses in patients with Alzheimer’s disease and mild cognitive impairment

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Abstract

Our goal was to investigate whether three-dimensional (3D) double inversion recovery (DIR) images can show alterations of gray matter volume (GMV) between Alzheimer’s disease (AD) patients and nondemented controls and to compare alterations of GMV between groups using DIR images and those using 3D T1-weighted (T1W) images. We included 25 subjects with mild or probable AD, 25 subjects with amnestic mild cognitive impairment (MCI), and 25 elderly cognitively normal (CN) subjects. Group differences in GMV among CN, MCI, and AD patients were tested by voxel-wise, one-way ANOVA. Additional region-of-interest-based comparisons of GMV differences among the three groups for DIR and T1WI were performed using ANCOVA. Finally, ROC curve analysis was performed. In the AD group compared with the CN and MCI groups, GMV was decreased in both DIR and T1W images. However, the areas showing GMV loss were larger in DIR images compared to those in T1W images. Amygdala had the highest area under curve value for both DIR and T1W images. DIR images were sensitive for identifying GMV loss in patients with AD compared with MCI and CN subjects and areas showing GMV loss identified with DIR were extended to more brain areas than those identified with T1W. With DIR, amygdala GMV is the most sensitive in differentiating between subject groups.

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Authors and Affiliations

  1. Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 134-727, Republic of Korea

    Geon-Ho Jahng & Chang-Woo Ryu

  2. Computational NeuroImage Analysis Lab, Department of Biomedical Engineering, Hanyang University, Sungdong P.O. Box 55, Seoul, 133-605, Republic of Korea

    Dong Kyun Lee & Jong-Min Lee

  3. Department of Neurology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 134-727, Republic of Korea

    Hak Young Rhee

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  1. Geon-Ho Jahng
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Correspondence to Geon-Ho Jahng.

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Source of Funding

This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI1C1238/A111282).

Conflicts of Interest

All authors declare that we have no conflict of interest.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

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This manuscript is in accordance with the statement of ethical standards for manuscripts. English was edited by a native English speaker from the Harrisco company (http://www.harrisco.net/).

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Supplemental table (DOCX 35 kb)

11682_2015_9469_MOESM2_ESM.docx

Supplement Figure. Result of gray matter volume (GMV) differences among the three subject groups of T1-weighted (T1W) images with resampling 2 mm and 4 mm slice thicknesses. AD, Alzheimer’s disease. MCI, mild cognitive impairment. CN, cognitively normal. GMV in AD with 2 mm and 4 mm slice thickness was almost the same result as that with 1 mm slice thickness. When we increased the slice thickness of T1W image, we did not find additional areas that showed significant GMV loss in AD. (DOCX 4771 kb)

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Jahng, GH., Lee, D.K., Lee, JM. et al. Double inversion recovery imaging improves the evaluation of gray matter volume losses in patients with Alzheimer’s disease and mild cognitive impairment. Brain Imaging and Behavior 10, 1015–1028 (2016). https://doi.org/10.1007/s11682-015-9469-2

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