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Effect of Toluene and Nutritional Status on Serotonin, Lipid Peroxidation Levels and NA+/K+-ATPase in Adult Rat Brain

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Abstract

The aim was to evaluate the effect of toluene and nutritional status on levels of serotonin (5-HT), 5-hydroxytryptophan (5-HTP), Na+/K+-ATPase, total ATPase and lipid peroxidation (TBARS) in rat brain. Study was conducted with malnourished (MN), well-nourished (WN) and normal Wistar rats. Three groups were formed for each nutritional status: control group I received 0.9% NaCl; toluene (1 g/kg) was administered to group II, and 1.5 g/kg to group III. Levels of 5-HT decreased (P < 0.05) in WN toluene groups, and 5-HTP decreased (P < 0.05) in the WN 1 g toluene and MN 1.5 g toluene groups. TBARS decreased (P < 0.05) in WN toluene groups. A trend to increase in Na+/K+-ATPase was found in WN and MN toluene groups, while total ATPase increased (P < 0.05) in the WN 1.5 g toluene group. The results suggest that high concentrations of toluene in single doses induce significant changes in the serotonergic system and alter membrane fluidity more perceptibly in the brain of adult animals with regular diet than in malnourished animals.

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Authors and Affiliations

  1. Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP), México

    David Calderón-Guzmán, Ivonne Espitia-Vázquez, Alejandra López-Domínguez & Bernardino Huerta-Gertrudis

  2. Laboratorio de Farmacología, Instituto Nacional de Pedíatria, Avenida Imán No.1, 3er piso Colonia Cuicuilco, CP 04530, Mexico City, México

    David Calderón-Guzmán, Ernestina Hernández-García & Hugo Juárez-Olguín

  3. Laboratorio de Bacteriología, INP, México

    Elvia Coballase-Urritia

  4. Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de, México

    Hugo Juárez-Olguín

  5. Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, México

    Alejandra López-Domínguez & Beatriz García-Fernández

Authors
  1. David Calderón-Guzmán
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  2. Ivonne Espitia-Vázquez
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  3. Alejandra López-Domínguez
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  4. Ernestina Hernández-García
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  5. Bernardino Huerta-Gertrudis
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  6. Elvia Coballase-Urritia
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  7. Hugo Juárez-Olguín
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  8. Beatriz García-Fernández
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Corresponding author

Correspondence to Hugo Juárez-Olguín.

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Calderón-Guzmán, D., Espitia-Vázquez, I., López-Domínguez, A. et al. Effect of Toluene and Nutritional Status on Serotonin, Lipid Peroxidation Levels and NA+/K+-ATPase in Adult Rat Brain. Neurochem Res 30, 619–624 (2005). https://doi.org/10.1007/s11064-005-2749-2

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  • DOI: https://doi.org/10.1007/s11064-005-2749-2

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