Neurotropic Properties of Novel Alkyl Derivatives of 1,3,4-Benzotriazepines

We studied the neurotropic properties of four novel derivatives of 1,3,4-benzotriazepines. The tested compounds were i.p. injected in doses of 1.0 or 10 mg/kg. We estimated motor and research activity of these compounds in the open-field test, their anticonvulsive effects under conditions of acute corazoleinduced seizures, anorixogenic and antidepressive effects, and also the acute and chronic toxicity of these agents. The latter properties of all studied compounds were found to be relatively low. In doses of 10 mg/kg, the tested agents decreased general motor activity, influenced the appetite of animals, and did not exert depressive effects. Therefore, the obtained data are indicative of the expedience of further search for alkylthio derivatives of 1,3,4-benzotriazepine with different functional groups connected to the heterocycle because such agents possess clearly pronounced sedative, anorexigenic, or orexigenic properties.