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Effects of follicle-stimulating hormone and vitamin A upon purinergic secretion by rat Sertoli cells

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Abstract

Follicle-stimulating hormone (FSH) and vitamin A (retinol) are two of the main regulators of the male reproductive system. Recently, it has been described that extracellular purines can affect some important reproductive-related functions in Sertoli cells and germinative cells, by activating specific purinergic receptors. In this work, we report that both FSH and retinol are able to induce changes in the levels of extracellular purines of cultured rat Sertoli cells. FSH induced an increase in adenosine, mainly caused by enhanced ecto-ATPase activity, while retinol increased xanthine and hypoxanthine levels, and decreased uric acid concentration by an unknown mechanism. These data indicate that purinergic signaling may be involved in the control and/or regulation of some of the reproductive-related actions of these hormones. (Mol Cell Biochem 278: 185–194, 2005)

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Authors and Affiliations

  1. Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

    Daniel Pens Gelain, Emerson André Casali, Ramatis Birnfeld de Oliveira, Luiz Fernando de Souza, Fabiano Barreto, Felipe Dal-Pizzol & José Cláudio Fonseca Moreira

  2. Departamento de Bioquímica, UFRGS, Laboratório 25. Rua Ramiro Barcelos 2600 anexo, CEP 90035-003, Porto Alegre, RS, Brazil

    Daniel Pens Gelain

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  1. Daniel Pens Gelain
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  2. Emerson André Casali
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  3. Ramatis Birnfeld de Oliveira
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  4. Luiz Fernando de Souza
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  6. Felipe Dal-Pizzol
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  7. José Cláudio Fonseca Moreira
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Correspondence to Daniel Pens Gelain.

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Gelain, D.P., Casali, E.A., de Oliveira, R.B. et al. Effects of follicle-stimulating hormone and vitamin A upon purinergic secretion by rat Sertoli cells. Mol Cell Biochem 278, 185–194 (2005). https://doi.org/10.1007/s11010-005-7500-4

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  • DOI: https://doi.org/10.1007/s11010-005-7500-4

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