Abstract
Epilepsy is reported to co-occur in individuals with autism spectrum disorder (ASD). Previous studies across the world have found prevalence estimates ranging from 4 to 38 %. We examined parent-reported prevalence of co-occurring epilepsy and ASD in the most recent U.S. National Survey of Children’s Health, 2011–2012. All analyses accounted for survey weights to account for the complex sampling design. In the overall analytic sample of 85,248 children ages 2–17, there were 1604 children with ASD (prevalence of 1.8 %) and 1083 children with epilepsy (prevalence of 1.2 %). Epilepsy was reported to co-occur in 8.6 % of ASD cases. In children with ASD, the co-occurrence of epilepsy was associated with increasing child age, female gender, intellectual disability, speech problems and lower socioeconomic status.
References
Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., & Charman, T. (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The special needs and Autism Project (SNAP). Lancet, 368(9531), 210–215. doi:10.1016/s0140-6736(06)69041-7.
Blumberg, S. J., Bramlett, M. D., Kogan, M. D., Schieve, L. A., Jones, J. R., & Lu, M. C. (2013). Changes in prevalence of parent-reported autism spectrum disorder in school-aged US children: 2007 to 2011–2012. National Health Statistics Reports, 65(20), 1–7.
Bolton, P. F., Carcani-Rathwell, I., Hutton, J., Goode, S., Howlin, P., & Rutter, M. (2011). Epilepsy in autism: Features and correlates. The British Journal of Psychiatry, 198(4), 289–294.
Cederlund, M., & Gillberg, C. (2004). One hundred males with Asperger syndrome: A clinical study of background and associated factors. Developmental Medicine & Child Neurology, 46(10), 652–660.
Danielsson, S., Gillberg, I. C., Billstedt, E., Gillberg, C., & Olsson, I. (2005). Epilepsy in young adults with autism: A prospective population-based follow-up study of 120 individuals diagnosed in childhood. Epilepsia, 46(6), 918–923. doi:10.1111/j.1528-1167.2005.57504.x.
Gillberg, C., Billstedt, E., Sundh, V., & Gillberg, I. C. (2010). Mortality in autism: A prospective longitudinal community-based study. Journal of Autism and Developmental Disorders, 40(3), 352–357.
Heaney, D. C., MacDonald, B. K., Everitt, A., Stevenson, S., Leonardi, G. S., Wilkinson, P., & Sander, J. W. (2002). Socioeconomic variation in incidence of epilepsy: Prospective community based study in south east England. BMJ, 325(7371), 1013–1016.
Idring, S., Lundberg, M., Sturm, H., Dalman, C., Gumpert, C., Rai, D., Magnusson, C., et al. (2015). Changes in prevalence of autism spectrum disorders in 2001–2011: Findings from the Stockholm youth cohort. Journal of Autism and Developmental Disorders, 45(6), 1766–1773. doi:10.1007/s10803-014-2336-y.
Jokiranta, E., Sourander, A., Suominen, A., Timonen-Soivio, L., Brown, A. S., & Sillanpää, M. (2014). Epilepsy among children and adolescents with autism spectrum disorders: A population-based study. Journal of Autism and Developmental Disorders, 44(10), 2547–2557.
Kielinen, M., Rantala, H., Timonen, E., Linna, S. L., & Moilanen, I. (2004). Associated medical disorders and disabilities in children with autistic disorder: A population-based study. Autism: The International Journal of Research and Practice, 8(1), 49–60. doi:10.1177/1362361304040638.
Kramer, M. S., Seguin, L., Lydon, J., & Goulet, L. (2000). Socio-economic disparities in pregnancy outcome: Why do the poor fare so poorly? Paediatric and Perinatal Epidemiology, 14(3), 194–210.
Liptak, G. S., Benzoni, L. B., Mruzek, D. W., Nolan, K. W., Thingvoll, M. A., Wade, C. M., & Fryer, G. E. (2008). Disparities in diagnosis and access to health services for children with autism: Data from the National Survey of Children’s Health. Journal of Developmental & Behavioral Pediatrics, 29(3), 152–160.
Lyall, K., Constantino, J. N., Weisskopf, M. G., Roberts, A. L., Ascherio, A., & Santangelo, S. L. (2014). Parental social responsiveness and risk of autism spectrum disorder in offspring. JAMA Psychiatry, 71(8), 936–942.
Mouridsen, S. E., Rich, B., & Isager, T. (1999). Epilepsy in disintegrative psychosis and infantile autism: A long-term validation study. Developmental Medicine and Child Neurology, 41(2), 110–114.
Schendel, D. E., Overgaard, M., Christensen, J., Hjort, L., Jorgensen, M., Vestergaard, M., & Parner, E. T. (2016). Association of psychiatric and neurologic comorbidity with mortality among persons with Autism Spectrum Disorder in a Danish population. JAMA Pediatrics, 170(3), 243–250. doi:10.1001/jamapediatrics.2015.3935.
Schieve, L. A., Rice, C., Yeargin-Allsopp, M., Boyle, C. A., Kogan, M. D., Drews, C., & Devine, O. (2012). Parent-reported prevalence of autism spectrum disorders in US-born children: An assessment of changes within birth cohorts from the 2003 to the 2007 National Survey of Children’s Health. Maternal and Child Health Journal, 16(1), 151–157.
Schieve, L. A., Tian, L. H., Baio, J., Rankin, K., Rosenberg, D., Wiggins, L., Devine, O., et al. (2014). Population attributable fractions for three perinatal risk factors for autism spectrum disorders, 2002 and 2008 autism and developmental disabilities monitoring network. Annals of Epidemiology, 24(4), 260–266. doi:10.1016/j.annepidem.2013.12.014.
Steffenburg, S., Steffenburg, U., & Gillberg, C. (2003). Autism spectrum disorders in children with active epilepsy and learning disability: Comorbidity, pre- and perinatal background, and seizure characteristics. Developmental Medicine and Child Neurology, 45(11), 724–730.
Sun, Y., Vestergaard, M., Pedersen, C. B., Christensen, J., Basso, O., & Olsen, J. (2008). Gestational age, birth weight, intrauterine growth and risk for epilepsy. American Journal of Epidemiology, 167(3), 262–270. doi:10.1093/aje/kwm316.
Tuchman, R., Cuccaro, M., & Alessandri, M. (2010). Autism and epilepsy: Historical perspective. Brain & Development, 32(9), 709–718. doi:10.1016/j.braindev.2010.04.008.
Tuchman, R., & Rapin, I. (2002). Epilepsy in autism. Lancet Neurology, 1(6), 352–358.
Valvo, G., Baldini, S., Brachini, F., Apicella, F., Cosenza, A., Ferrari, A. R., Sicca, F., et al. (2013). Somatic overgrowth predisposes to seizures in autism spectrum disorders. PLoS One, 8(9), e75015. doi:10.1371/journal.pone.0075015.
Viscidi, E. W., Triche, E. W., Pescosolido, M. F., McLean, R. L., Joseph, R. M., Spence, S. J., & Morrow, E. M. (2013). Clinical characteristics of children with autism spectrum disorder and co-occurring epilepsy. PLoS One, 8(7), e67797. doi:10.1371/journal.pone.0067797.
Yasuhara, A. (2010). Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). Brain & Development, 32(10), 791–798. doi:10.1016/j.braindev.2010.08.010.
Author Contributions
ST and BL participated in study conception and design; Acquisition of data: Analysis and interpretation of data: Drafting of manuscript: Critical revision. DR and MH participated in: Analysis and interpretation of data: Drafting of manuscript: Critical revision.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The National Survey of Children’s Health study protocol was approved by the National Center for Health Statistics Research Ethics Review Board and the Abt Associates Institutional Review Board.
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Thomas, S., Hovinga, M.E., Rai, D. et al. Brief Report: Prevalence of Co-occurring Epilepsy and Autism Spectrum Disorder: The U.S. National Survey of Children’s Health 2011–2012. J Autism Dev Disord 47, 224–229 (2017). https://doi.org/10.1007/s10803-016-2938-7
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DOI: https://doi.org/10.1007/s10803-016-2938-7