Skip to main content
SpringerLink
Log in

Formation of magnetoliposomes using self-assembling 1,4-dihydropyridine derivative and maghemite γ-Fe2O3 nanoparticles

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

This work demonstrates studies of ferromagnetic nanoparticle functionalization by a lipid-like compound, cationic pyridine amphiphile derived from 1,4-dihydropyridine, 1,1'-{[3,5-bis(dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]dimethanediyl}dipyridinium dibromide, and determination of optimal conditions for the production of magnetoliposomes. The following methodologies, such as sonication, spontaneous swelling, and reverse-phase evaporation, were used for the preparation of liposomes. Ferrofluid containing γ-Fe2O3 nanoparticles with a positively charged surface was used for the preparation of magnetoliposomes. The obtained soft matter objects were studied by optical microscopy, transmission electron microscopy, and dynamic light scattering techniques. The optimal conditions for the production of magnetoliposomes were found by spontaneous swelling and reverse-phase evaporation methods using ferrofluid with positively charged γ-Fe2O3 nanoparticles and cationic 1,4-dihydropyridine derivative.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9

Similar content being viewed by others

References

  1. Hyvönen, Z.; Plotniece, A.; Reine, I.; Chekavichus, B.; Duburs, G.; Urtti, A. Biochim. Biophys. Acta. 2000, 1509, 451.

    Article  Google Scholar 

  2. Triggle, D. J. Cell. Mol. Neurobiol. 2003, 23, 293.

  3. Triggle, D. J. Mini-Rev. Med. Chem. 2003, 3, 215.

  4. Pajuste, K.; Hyvönen, Z.; Petrichenko, O.; Kaldre, D.; Rucins, M.; Cekavicus, B.; Ose, V.; Skrivele, B.; Gosteva, M.; Morin- Picardat, E.; Plotniece, M.; Sobolev, A.; Duburs, G.; Ruponen, M.; Plotniece, A. New J. Chem. 2013, 37, 3062.

    Article  CAS  Google Scholar 

  5. Yang, L.; Sun, X.; Yang, F.; Zhao, C.; Zhang, L.; Zu, Y. Food Chem. 2007, 128, 1152.

    Article  Google Scholar 

  6. Nie, Z.; Liu, K. J.; Chong, C. J.; Wang, L. F.; Yang, Y.; Tian, Q.; Liu, Y. Free Radical Biol. Med. 2007, 43, 1243.

    Article  CAS  Google Scholar 

  7. Basnet, P.; Hussain, H.; Tho, I.; Skalko-Basnet, N. J. Farm. Sci. 2012, 101, 598.

    CAS  Google Scholar 

  8. Varadan, V. K.; Chen, L.; Xie, J. Nanomedicine; Wiley: Hoboken, 2008, p. 152.

  9. Skouras, A.; Mourtas, S.; Markoutsa, E.; De Golstein, M. C.; Wallon, C.; Sarah, C. Nanomedicine: NBM 2011, 7, 572.

    Article  CAS  Google Scholar 

  10. Taukulis, R.; Cēbers, A. Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys. 2012, 86, 061405.

    Article  CAS  Google Scholar 

  11. Covaliu, C. I.; Paraschiv, G.; Biris, S.-S.; Jitaru, I.; Vasile, E.; Diamandescu, L.; Cirkovic Velickovic, T.; Krstic, M.; Ionita, V.; Iovu, H.; Mateis, E. Appl. Surf. Sci. 2013, 285P, 86.

    Article  Google Scholar 

  12. Magro, M.; Sinigaglia, G.; Nodari, L.; Tucek, J.; Polakova, K.; Marusak, Z.; Cardillo, S.; Salviulo, G.; Russo, U.; Stevanato, R.; Zboril, R.; Vianello, F. Acta Biomater. 2012, 8, 2068.

    Article  CAS  Google Scholar 

  13. Gupta, A. K.; Gupta, M. Biomaterials 2005, 26, 3995.

    Article  CAS  Google Scholar 

  14. Dobson, J. Nat. Nanotechnol. 2008, 3, 139.

    Article  CAS  Google Scholar 

  15. Mazuel, F.; Reffay, M.; Du, V.; Bacri, J.-C.; Rieu, J.-P.; Wilhelm, C. Phys. Rev. Lett. 2015, 114, 098105.

    Article  Google Scholar 

  16. Shinkai, M. J. Biosci. Bioeng. 2002, 94, 606.

    Article  CAS  Google Scholar 

  17. Mahmoudi, M.; Sant, S.; Wang, B.; Laurent, S.; Sen, T. Adv. Drug Delivery Rev. 2011, 63, 24.

    Article  CAS  Google Scholar 

  18. Bacri, J.-C.; Cabuil, V.; Cebers, A.; Menager, C.; Perzynski, R. Europhys. Lett. 1996, 33, 235.

    Article  CAS  Google Scholar 

  19. Beune, G.; Dubertret, B.; Clément, O.; Vayssettes, C.; Cabuil, V.; Ménager, C. Angew. Chem., Int. Ed. 2007, 46, 5421.

    Article  Google Scholar 

  20. Petrichenko, O.; Erglis, K.; Cebers, A.; Plotniece, A.; Pajuste, K.; Béalle, G.; Menager, C.; Dubois, E.; Perzynski, R. Eur. Phys. J. E: Soft Matter Biol. Phys. 2013, 36, 9.

    Article  CAS  Google Scholar 

  21. Massart, R. C. R. Acad. Sci., Ser. C. 1980, 291, 1.

  22. Bee, A.; Massart, R.; Neveu, S. JMMM 1995, 149, 6.

    Article  CAS  Google Scholar 

  23. Béalle, G.; Di Corato, R.; Kolosnjaj-Tabi, J.; Dupuis, V.; Clement, O.; Gazeau, F.; Wilhelm, C.; Menager, C. Langmuir 2012, 28, 11834.

    Article  Google Scholar 

  24. Beune, G.; Ménager, C.; Cabuil, V. J. Phys. Chem. B 2008, 112, 7424.

    Article  Google Scholar 

  25. Ménager, C.; Meyer, M.; Cabuil, V.; Cebers, A.; Bacri, J.-C.; Perzynski, R. Eur. Phys. J. E: Soft Matter Biol. Phys. 2002, 7, 325.

    Google Scholar 

  26. Sandre, O.; Ménager, C.; Prost, J.; Bacri, J.-C.; Cebers, A. Phys. Rev. E: Soft Matter Biol. Phys. 2000, 62, 3865.

    Article  CAS  Google Scholar 

  27. Menager, C.; Cabuil, V. Colloid Polym. Sci. 1994, 272, 1295.

    Article  CAS  Google Scholar 

  28. http://rsb.info.nih.gov/ij/

  29. Gradzielski, M. J. Phys.: Condens. Matter 2003, 15, R655.

    CAS  Google Scholar 

Download references

The support from OSMOSE program No 22497YE and INNOVABALT (REGPOT – CT-2013-316149) project (for O. Petrichenko) is gratefully acknowledged. The authors are indebted to M. Maiorov from Institute of Physics of the University of Latvia for the measurement of magnetic properties of nanoparticles and B. Skrivele from the Latvian Institute of Organic Synthesis for the registration of AFM images.

Author information

Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St, Riga, LV-1006, Latvia

    Oksana Petrichenko, Aiva Plotniece & Karlis Pajuste

  2. University of Latvia, 8 Zellu St, Riga, LV-1002, Latvia

    Oksana Petrichenko & Andrejs Cēbers

  3. Latvian Biomedical Research and Study Centre, Ratsupites St, Riga, LV-1067, Latvia

    Velta Ose

Authors
  1. Oksana Petrichenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aiva Plotniece
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Karlis Pajuste
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Velta Ose
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Andrejs Cēbers
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Oksana Petrichenko.

Additional information

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2015, 51(7), 672–677

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Petrichenko, O., Plotniece, A., Pajuste, K. et al. Formation of magnetoliposomes using self-assembling 1,4-dihydropyridine derivative and maghemite γ-Fe2O3 nanoparticles. Chem Heterocycl Comp 51, 672–677 (2015). https://doi.org/10.1007/s10593-015-1755-9

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-015-1755-9

Keywords

Search

Navigation