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Synthesis of Quinazoline-2,4(1H,3H)-Diones from Carbon dioxide and 2-Aminobenzonitriles Using MgO/ZrO2 as a Solid Base Catalyst

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Abstract

The synthesis of quinazoline-2,4(1H,3H)-diones from carbon dioxide and 2-aminobenzonitriles using MgO/ZrO2 as a novel and efficient heterogeneous base catalyst is reported. The synthesized MgO/ZrO2 catalyst was characterized by XRD, FTIR and its basic properties were measured using CO2 temperature programed desorption analysis. The effects of various reaction parameters were investigated in detail. A wide variety of aromatic aminobenzonitriles and five member N-heterocyclic carbonitriles were synthesized using this protocol.

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Acknowledgments

The authors are thankful for financial support for this work from the Council of Scientific & Industrial Research (CSIR), India though Grant no. 09/019(0073)2009-EMR-1.

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Authors and Affiliations

  1. Department of Chemistry, Institute of Chemical Technology, (Autonomous), N. Parekh Marg, Matunga, Mumbai, 400 019, India

    Yogesh P. Patil, Pawan J. Tambade, Kalpesh D. Parghi, Radha V. Jayaram & Bhalchandra M. Bhanage

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  1. Yogesh P. Patil
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  2. Pawan J. Tambade
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  3. Kalpesh D. Parghi
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  4. Radha V. Jayaram
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  5. Bhalchandra M. Bhanage
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Correspondence to Bhalchandra M. Bhanage.

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Patil, Y.P., Tambade, P.J., Parghi, K.D. et al. Synthesis of Quinazoline-2,4(1H,3H)-Diones from Carbon dioxide and 2-Aminobenzonitriles Using MgO/ZrO2 as a Solid Base Catalyst. Catal Lett 133, 201–208 (2009). https://doi.org/10.1007/s10562-009-0126-5

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